TL;DR: These are eyedrops which cure your growing inability to read as you age and last for 8 hours.
[…] presbyopia affects nearly one in two adults over 40, yet treatment options have remained largely static for decades, confined to optical corrections or surgical procedures. The FDA’s green light for Vizz — the first drop-based, aceclidine-containing ophthalmic formulation approved specifically for near vision correction — was driven by robust phase 3 trial data demonstrating consistent, clinically meaningful improvements in reading acuity without compromising distance vision.
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Vizz’s mechanism pivots on aceclidine’s miotic action, gently constricting the pupil to enhance depth of focus—akin to a dynamic pinhole effect tailored for near tasks. Unlike lens-altering approaches that hinge on accommodation or optical overlays, this ophthalmic solution targets the iris sphincter muscle, inducing a 1.5–2 mm reduction in pupil diameter that sharpens close-range vision without distorting distance clarity. Pharmacologically, aceclidine acts as a selective cholinergic agonist, offering a predictable pharmacokinetic profile with onset of action within 30 minutes and sustained efficacy for up to 8 hours. This mechanism not only underpins clinical efficacy but also directly informs patient-centric dosing strategies. Device-based pupillometry studies confirm that the targeted miotic effect avoids excessive constriction that could impair scotopic performance. Clinicians can customize dosing to patient pupil response, initiating treatment with a classroom-based trial to fine-tune visual outcomes.
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over 75% of participants achieving at least one line of near visual acuity gain on ETDRS charts […] At peak effect, 62% of subjects recorded two or more lines of improvement, and gains persisted through an eight-hour window sufficient for typical daytime activities, from mobile device reading to detailed crafts. Reported adverse effects were mild and transient, primarily limited to brief brow ache or slight dimming of ambient light, without significant impact on distance vision or ocular surface health.
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High patient compliance with Vizz arises from its once-daily dosing schedule, rapid visual benefit, and elimination of cumbersome lens handling
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This seems like a better alternative to Orthrokeratology, where you wear contact lenses at night to reshape your eyes and you can see properly for about a day for nearsightedness. Of course, you can’t use these eyedrops for farsignedness and you can use orthokeratolgoy for that.
Robin Edgar
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