Simple light trick reveals hidden organic pathways in microscopic detail

Every tissue in the human body contains exceptionally small fibers that help coordinate how organs move, function and communicate. Muscle fibers guide physical force, intestinal fibers support the motion of the digestive tract, and brain fibers carry electrical signals that allow different regions to exchange information. Together, these intricate fiber systems help shape the structure of each organ and keep them operating properly.

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Although these microscopic structures play essential roles, they have long been challenging to study. Researchers have struggled to determine how fibers are oriented inside tissues, which has made it difficult to fully understand how they change in health and disease.

A Simple Method for Revealing Hidden Microstructure

A research team led by Marios Georgiadis, PhD, instructor of neuroimaging, has now introduced an approach that makes these hard-to-see fiber patterns visible with exceptional clarity and at a relatively low cost.

Their technique, described in Nature Communications, is known as computational scattered light imaging (ComSLI). It can reveal the orientation and organization of tissue fibers at micrometer resolution on virtually any histology slide, regardless of how it was stained or preserved — even if the slide is many decades old.

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ComSLI relies on a basic physical principle: when light encounters microscopic structures, it scatters in different directions based on their orientation. By rotating the light source and recording how the scattering signal changes, researchers can reconstruct the direction of the fibers within each pixel of an image.

The method requires only a rotating LED light and a microscope camera, making the setup accessible compared with other forms of advanced microscopy. After the images are collected, software analyzes delicate patterns in the scattered light to generate color-coded maps of fiber orientation and density, known as microstructure-informed fiber orientation distributions.

ComSLI is not limited by sample preparation. It works with formalin-fixed, paraffin-embedded sections (a standard in hospitals and pathology labs) as well as fresh-frozen, stained or unstained slides.

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“This is a tool that any lab can use,” Zeineh said. “You don’t need specialized preparation or expensive equipment. What excites me most is that this approach opens the door for anyone, from small research labs to pathology labs, to uncover new insights from slides they already have.”

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To test the limits of the method, the researchers analyzed a brain section prepared in 1904. Even in this century-old sample, ComSLI identified intricate fiber patterns, allowing scientists to study historical specimens and explore how structural features evolve across generations of disease.

Applications Beyond the Brain

Although first designed for brain research, ComSLI also works well in other tissues. The team used it to study muscle, bone and vascular samples, each revealing unique fiber arrangements tied to their biological functions.

In tongue muscle, the method highlighted layered fiber orientations linked to movement and flexibility. In bone, it captured collagen fibers that align with mechanical stress. In arteries, it showed alternating collagen and elastin layers that support both strength and elasticity.

This ability to map fiber orientation across species, organs and archival specimens could significantly change how scientists investigate structure and function.

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Story Source:

Materials provided by Stanford Medicine. Note: Content may be edited for style and length.


Journal Reference:

  1. Marios Georgiadis, Franca auf der Heiden, Hamed Abbasi, Loes Ettema, Jeffrey Nirschl, Hossein Moein Taghavi, Moe Wakatsuki, Andy Liu, William Hai Dang Ho, Mackenzie Carlson, Michail Doukas, Sjors A. Koppes, Stijn Keereweer, Raymond A. Sobel, Kawin Setsompop, Congyu Liao, Katrin Amunts, Markus Axer, Michael Zeineh, Miriam Menzel. Micron-resolution fiber mapping in histology independent of sample preparation. Nature Communications, 2025; 16 (1) DOI: 10.1038/s41467-025-64896-9

Source: Simple light trick reveals hidden brain pathways in microscopic detail | ScienceDaily

Instacart Charging Customers up to 25% Different Prices for Same Products

How much does a carton of eggs cost? Depends on who you are. A new study produced in collaboration with policy group Groundwork Collaborative, Consumer Reports, and More Perfect Union found that people who purchased the exact same product from the exact same store at the exact same time were charged different prices—sometimes up to nearly 25% more—when placing the order on Instacart.

The study tapped 437 volunteer shoppers in four cities who were put in groups that were synced up virtually to add items from a specific grocery store into their Instacart shopping carts at the same time. They then reported the prices that appeared for those researchers to determine if people were being charged different prices for the same goods.

The result was a pretty resounding “Yes.” According to the study, nearly three-quarters of all grocery items tested in the experiment produced multiple prices across shoppers, including some products that showed five different prices for the same product.

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Researchers reported that the final total of the Instacart shopping carts varied by an average of 7% despite every item and condition being identical.

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According to Consumer Reports, the company confirmed the study accurately reflected its pricing strategies, which it claims to only do at 10 partnering grocery retailers that it chose not to name.

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While Instacart didn’t name the retailers they have partnered with for this program, the study did name where they performed their tests. One retailer was Target, and they found varying prices on items sold through Instacart from the retailer. Target told Groundwork Collaborative that it has no business relationship with Instacart and “does not directly share any pricing information with Instacart or dictate what Instacart prices appear on their platform.” Instacart acknowledged to the publication that it scrapes Target’s prices and adds an upcharge to offset “operating and technology costs.” So Target was seemingly not one of the 10 retail partners, but shoppers there were still exposed to price variance. Instacart claims it has ended pricing experiments at Target.

It certainly seems like the pricing discrepancies are an example of surveillance pricing, where consumers are served different prices based on information the platform knows about them. The study didn’t find any clear correlation that would link certain shopper demographic data and the prices they were presented, and Instacart told Consumer Reports that it doesn’t use any personal or demographic data from users in its pricing experiments and instead explained that customers are randomly assigned to price groups.

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“These tests are not dynamic pricing – prices never change in real-time, including in response to supply and demand. The tests are never based on personal or behavioral characteristics — they are completely randomized,” an Instacart spokesperson told Gizmodo.

So Instacart’s varied pricing is allegedly part of an experiment that randomly assigns shoppers to different pricing groups, but brands whose goods are available on Instacart can use the company’s data-driven pricing platform to serve different prices based on different demographic data. For the end user, that likely feels like a distinction without a difference, as they are ultimately seeing different prices based on conditions that are outside of their control.

Source: Instacart Charging Customers Different Prices for Same Products, Study Finds

Australias Social Media Ban goes into Effect

The BBC has a live page following the ban and surprise surprise – it didn’t take long for people to circumvent the ban at all, with alternative social media being used (eg Lemon8, Yope, etc), VPNs being used (and the use of VPNs being threatened by ministers), pleas by campaigners asking for parents not to help circumvent the rules, etc.

That the ban won’t work is predictable. It will force kids into hiding, where they will be beyond the oversight of absolutely anyone. Worse, it will leave them with no help when things do go wrong – who is going to be complaining to their parents or the police about cyberbullying when they are using an illegal platform where they are being bullied on?

The age limit of 16 is entirely arbitrary too. Some kids develop faster than others and some very much slower. With science showing that adulthood starts at 32 (and looking at how far right politics and belief in populist nonsense is going globally, in many cases seemingly never), mature children are being punished and immature young adults are being exposed to content that they are not equipped to handle.

The goal – stopping toxic, unwanted behaviors in social media platforms – is a good one. By now we should be able to define these unwanted behaviours (eg no false news; no body shaming; no targeted abuse; no political preferences in feeds; who really needs video calls with groups of more than 6 people on a social media platform anyway? etc) and test them. To throw a random age line at the problem doesn’t solve it. How about for every instance of one of these behaviours a huge fine is levied (eg $1 million or above – the scale of the profits of the social media companies beggars belief, so only huge fines will make them feel the cost / benefit of paying the fine / fixing the problem lies in the fixing the problem side of things) – something that these behemoths cannot ignore. And if too many transgressions are detected in a certain period (eg 100 fines per week) then the platform is closed entirely for a certain period (weeks / months). This will incentivise the social media platforms to fix the problems which is what we want instead of driving kids into hiding and exposing them to a much more dangerous social media landscape.

Congress strips right-to-repair from military spending bill despite bipartisan support. Why? Lobbying Money!

Congress has released the final version of the 2026 National Defense Authorization Act (NDAA), and critics have been quick to point out that previously proposed rules giving the US military the right to repair its equipment without having to rely on contractors have gone missing.

The House and Senate versions of the NDAA passed earlier both included provisions that would have extended common right-to-repair rules to US military branches, requiring defense contractors to provide access to technical data, information, and components that enabled military customers to quickly repair essential equipment. Both of those provisions were stripped from the final joint-chamber reconciled version of the bill, published Monday, right-to-repair advocates at the US Public Interest Research Group (PIRG) pointed out in a press release.

Support for the military’s right to repair is so broad, and it’s one of the few issues where liberal Democrats in Congress are aligned with President Trump. Senators Elizabeth Warren (D-MA) and Tim Sheehy (R-MT) even introduced a bill over the summer that would have legislated “fair and reasonable access” to necessary parts and information that would enable the US military to fix gear faster than farmers with broken John Deere tractors. That bill, referred to the Senate Armed Services Committee in July, hasn’t budged since.

In other words, the 2026 NDAA was the latest best hope to give the troops some repairability leeway.

“Despite support from Republicans, Democrats, the White House, and key military leaders, troops will keep waiting for repairs they could perform themselves,” PIRG legislative associate Charlie Schuyler said in the group’s statement. “Taxpayers will keep paying inflated costs. And in some cases, soldiers might not get the equipment they need when they need it most.”

The US military has been waging a war to achieve the right to repair its own equipment for some time, with the effort accelerating during the second Trump administration. The US Army, for example, has taken it upon itself to demand that future contracts include right to repair provisions, while the Navy has told Congress that it wants the right to repair its own gear, too.

In the Navy’s case, part of that was motivated by incredibly costly repairs needed for the USS Gerald R. Ford, a nuclear-powered aircraft carrier with a crew of 4,500 that, at one point, had six of eight kitchen ovens out of commission. The support contract for ship maintenance barred sailors from fixing the ovens themselves, even if they could do it.

“The Trump administration, in addition to the Secretaries of the Army, Navy, and Air Force, have all expressed support for military Right to Repair,” PIRG said in its press release.

Isaac Bowers, PIRG’s federal legislative director, told The Register that, while it’s hard to fathom a reason the repairability provisions were stripped from the final bill, he has a sneaking suspicion: Defense industry lobbying.

The right-to-repair provisions “were opposed by a defense industry that has deep pockets, influence on Capitol Hill and a lot invested in the U.S. military continuing to pay their inflated sustainment costs,” Bowers told us.

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Source: Congress strips right-to-repair from military spending bill • The Register

Colour Epaper Digital Screens Takes Color Resolution to 25,000 pixels per inch

Visual displays have steadily gotten smaller and held closer to our eyes as our viewing habits have shifted from cinema screens to TVs to computers, smartphones and virtual reality. This shift has required higher image resolution (usually through increased pixel counts) to provide enough detail. Conventional light-emitting pixels work poorly below a certain size: brightness drops, and colors bleed. The same isn’t true for reflective displays such as those used in many e-readers, whose pixels reflect ambient light rather than emitting their own—but creating those pixels typically requires larger components.

A new reflective display could shatter those restrictions with resolutions beyond the limit of human perception. In a recent study in Nature, scientists describe a reflective retina e-paper that can display color video on screens smaller than two square millimeters across.

The researchers used nanoparticles whose size and spacing affect how light is scattered, tuning them to create red, green and blue subpixels. The material is electrochromic, so its light absorption and reflection can be controlled with electrical signals. With this setup, “metapixels” consisting of the three subpixels can generate any color if you deliver appropriate signals.

Each pixel is only 560 nanometers wide, creating a resolution above 25,000 pixels per inch—more than 50 times that of current smartphones. “We can make displays a similar size as your pupil, with a similar number of pixels as photoreceptors in your eyes,” says study co-author Kunli Xiong of Uppsala University in Sweden. “So we can create virtual worlds very close to reality.”

Graphic compares the scale, resolution and color quality of an image of Gustav Klimt’s painting The Kiss on a phone screen versus the e-paper.

E-paper screens also have relatively low energy requirements; the pixels retain their color for some time, so power is generally needed only when colors change. “It uses ultralow power,” Xiong says. “For very small devices, it is not easy to integrate large batteries, so that energy saving becomes even more important.”

The team demonstrated the technology with a version of The Kiss by Austrian painter Gustav Klimt and a three-dimensional butterfly image. “People have made these kinds of materials before, but usually they produce poor colors,” says Jeremy Baumberg, a nanotechnologist at the University of Cambridge, who studies how nanoscale materials interact with light. In comparison, the design of Xiong and his colleagues’ subpixels “generates colors that look more compelling than I’ve seen before,” Baumberg says.

These pixels can be rapidly controlled, enabling a reasonable refresh rate—but the necessary electronics for such a high resolution do not yet exist. Xiong and his colleagues anticipate that engineering companies will begin to develop such systems.

Meanwhile Xiong’s team plans to optimize other aspects of the technology such as its speed and lifetime. “Every time you switch [colors], the material’s structure changes, and eventually it crumbles,” Baumberg says—similar to how batteries decay. He estimates that it’ll be five to 10 years before we see commercially available devices.

Source: Breakthrough in Digital Screens Takes Color Resolution to Incredibly Small Scale | Scientific American

Why Local Airports Matter More Than Ever

Europe’s map is not just its capitals and hubs: it is a constellation of cultures and communities. It is a simple fact that many of these communities, industrial towns, university centres, and touristic villages depend on reliable, affordable air links to the rest of Europe and beyond – provided by their regional airports.

For them, the nearest airport is a lifeline and their sole link to the world. If the EU is serious about cohesion, competitiveness and the green transition for aviation, then it must recognise the strategic value of regional airports in ensuring no citizen is left behind.

This means the EU must also recognise that these airports, which provide such essential connections, are not often in a position to be profitable and self-funding. This is the role of State aid: to ensure citizens across Regional communities are not isolated from education, employment, culture and the opportunities that come from being connected.

This is why ACI EUROPE continues to raise alarms about the need to extend EU guidelines that allow well-governed State aid to small airports. Those guidelines are at risk in an ongoing European Commission evaluation.

Here is the policy rub: the EU’s current State Aid Aviation Guidelines assume that small airports will adjust to become financially viable over time. The reality is that many will not be able to, through no fault of their own. High fixed costs, lumpy seasonality and airline market power in route development negotiations act against them. That is why extending the possibility for operating state aid beyond 2027 for airports up to 1 million passengers, with sensible intensity thresholds and guardrails, is not market distortion. It is the targeted correction of a structural market failure that preserves connectivity possibilities where the market alone undersupplies it.

The fiscal scale is modest; the payoff is large. Airports up to 1 million passengers account for only about 2.5% of total EU traffic – so the envelope of potential operating support is limited, precise, and efficient: the social and economic returns are concentrated in exactly the places EU cohesion policy is meant to serve. Put differently: a relatively small public outlay secures links that keep regions investable, stem brain drain, and maintain equal access to essential services.

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Source: Why Local Airports Matter More Than Ever | Euractiv

For simple politicians, it is easy to think in simple solutions: on paper having huge airports (owned by a huge company with huge lobbying power) servicing centrally will seem more efficient. With connections, it is not about efficiency, it is about quantity – seeing that as many points are connected is more important than that the existing connections have huge throughput.

Google and Apple partner on better Android-iPhone switching 

The latest Android Canary build is available today and it features work by Apple and Google to make switching between Android and iPhone devices easier.

A joint collaboration between the two companies aims to make transferring data between Android and iOS easier. Google and Apple tell us that this will be available during the device setup process.

This work is beginning to go live today with Android Canary 2512 (ZP11.251121.010) on all Pixel devices, while this is coming with a future iOS 26 developer beta. Ahead of launch, this easier switching will add more functionality and support for additional data types that are transferred over.

As always, Android Canary and iOS developer betas are not intended for general use, and might have other performance issues. On the Google side, these features will eventually make their way to the Android Beta before launch.

It’s not clear when the final version of this improved switching is going live, with Android support happening on a device-by-device basis. Until then, there is Apple’s Move to iOS app on Android and Google’s Android Switch app on iOS.

Source: Google and Apple partner on better Android-iPhone switching 

The year age verification laws came for the open internet

When the nonprofit Freedom House recently published its annual report, it noted that 2025 marked the 15th straight year of decline for global internet freedom. The biggest decline, after Georgia and Germany, came within the United States.

Among the culprits cited in the report: age verification laws, dozens of which have come into effect over the last year. “Online anonymity, an essential enabler for freedom of expression, is entering a period of crisis as policymakers in free and autocratic countries alike mandate the use of identity verification technology for certain websites or platforms, motivated in some cases by the legitimate aim of protecting children,” the report warns.

Age verification laws are, in some ways, part of a years-long reckoning over child safety online, as tech companies have shown themselves unable to prevent serious harms to their most vulnerable users. Lawmakers, who have failed to pass data privacy regulations, Section 230 reform or any other meaningful legislation that would thoughtfully reimagine what responsibilities tech companies owe their users, have instead turned to the blunt tool of age-based restrictions — and with much greater success.

Over the last two years, 25 states have passed laws requiring some kind of age verification to access adult content online. This year, the Supreme Court delivered a major victory to backers of age verification standards when it upheld a Texas law requiring sites hosting adult content to check the ages of their users.

Age checks have also expanded to social media and online platforms more broadly. Sixteen states now have laws requiring parental controls or other age-based restrictions for social media services. (Six of these measures are currently in limbo due to court challenges.) A federal bill to ban kids younger than 13 from social media has gained bipartisan support in Congress. Utah, Texas and Louisiana passed laws requiring app stores to check the ages of their users, all of which are set to go into effect next year. California plans to enact age-based rules for app stores in 2027.

These laws have started to fragment the internet. Smaller platforms and websites that don’t have the resources to pay for third-party verification services may have no choice but to exit markets where age checks are required. Blogging service Dreamwidth pulled out of Mississippi after its age verification laws went into effect, saying that the $10,000 per user fines it could face were an “existential threat” to the company. Bluesky also opted to go dark in Mississippi rather than comply. (The service has complied with age verification laws in South Dakota and Wyoming, as well as the UK.) Pornhub, which has called existing age verification laws “haphazard and dangerous,” has blocked access in 23 states.

Pornhub is not an outlier in its assessment. Privacy advocates have long warned that age verification laws put everyone’s privacy at risk. Practically, there’s no way to limit age verification standards only to minors. Confirming the ages of everyone under 18 means you have to confirm the ages of everyone. In practice, this often means submitting a government-issued ID or allowing an app to scan your face. Both are problematic and we don’t need to look far to see how these methods can go wrong.

Discord recently revealed that around 70,000 users “may” have had their government IDs leaked due to an “incident” involving a third-party vendor the company contracts with to provide customer service related to age verification. Last year, another third-party identity provider that had worked with TikTok, Uber and other services exposed drivers’ licenses. As a growing number of platforms require us to hand over an ID, these kinds of incidents will likely become even more common.

Similar risks exist for face scans. Because most minors don’t have official IDs, platforms often rely on AI-based tools that can guess users’ ages. A face scan may seem more private than handing over a social security number, but we could be turning over far more information than we realize, according to experts at the Electronic Frontier Foundation (EFF).

“When we submit to a face scan to estimate our age, a less scrupulous company could flip a switch and use the same face scan, plus a slightly different algorithm, to guess our name or other demographics,” the organization notes. “A poorly designed system might store this personal data, and even correlate it to the online content that we look at. In the hands of an adversary, and cross-referenced to other readily available information, this information can expose intimate details about us.”

These issues aren’t limited to the United States. Australia, Denmark and Malaysia have taken steps to ban younger teens from social media entirely. Officials in France are pushing for a similar ban, as well as a “curfew” for older teens. These measures would also necessitate some form of age verification in order to block the intended users. In the UK, where the Online Safety Act went into effect earlier this year, we’ve already seen how well-intentioned efforts to protect teens from supposedly harmful content can end up making large swaths of the internet more difficult to access.

The law is ostensibly meant to “prevent young people from encountering harmful content relating to suicide, self-harm, eating disorders and pornography,” according to the BBC. But the law has also resulted in age checks that reach far beyond porn sites. Age verification is required to access music on Spotify. It will soon be required for Xbox accounts. On X, videos of protests have been blocked. Redditors have reported being blocked from a lengthy number of subreddits that are marked NSFW but don’t actually host porn, including those related to menstruation, news and addiction recovery. Wikipedia, which recently lost a challenge to be excluded from the law’s strictest requirements, is facing the prospect of being forced to verify the ages of its UK contributors, which the organization has said could have disastrous consequences.

The UK law has also shown how ineffective existing age verification methods are. Users have been able to circumvent the checks by using selfies of video game characters, AI-generated images of ID documents and, of course, Virtual Private Networks (VPNs).

As the EFF notes, VPNs are incredibly widely used. The software allows people to browse the internet while masking their actual location. They’re used by activists and students and people who want to get around geoblocks built into streaming services. Many universities and businesses (including Engadget parent company Yahoo) require their students and workers to use VPNs in order to access certain information. Blocking VPNs would have serious repercussions for all of these groups.

The makers of several popular VPN services reported major spikes in the UK following the Online Safety Act going into effect this summer, with ProtonVPN reporting a 1,400 percent surge in sign-ups. That’s also led to fears of a renewed crackdown on VPNs. Ofcom, the regulator tasked with enforcing the law, told TechRadar it was “monitoring” VPN usage, which has further fueled speculation it could try to ban or restrict their use. And here in the States, lawmakers in Wisconsin have proposed an age verification law that would require sites that host “harmful” content to also block VPNs.

While restrictions on VPNs are, for now, mostly theoretical, the fact that such measures are even being considered is alarming. Up to now, VPN bans are more closely associated with authoritarian countries without an open internet, like Russia and China. If we continue down a path of trying to put age gates up around every piece of potentially objectionable content, the internet could get a lot worse for everyone.

Source: The year age verification laws came for the open internet