A lot of medical science in question

This is the second time scientific results are being questioned on a very deep level in a very short time. It’s a very disturbing trend.

In just the last two months, two pillars of preventive medicine fell. A major study concluded there’s no good evidence that statins drugs like Lipitor and Crestor help people with no history of heart disease. The study, by the Cochrane Collaboration, a global consortium of biomedical experts, was based on an evaluation of 14 individual trials with 34,272 patients. Cost of statins: more than $20 billion per year, of which half may be unnecessary. Pfizer, which makes Lipitor, responds in part that “managing cardiovascular disease risk factors is complicated”. In November a panel of the Institute of Medicine concluded that having a blood test for vitamin D is pointless: almost everyone has enough D for bone health 20 nanograms per milliliter without taking supplements or calcium pills. Cost of vitamin D: $425 million per year.

Ioannidis, 45, didn’t set out to slay medical myths. A child prodigy he was calculating decimals at age 3 and wrote a book of poetry at 8, he graduated first in his class from the University of Athens Medical School, did a residency at Harvard, oversaw AIDS clinical trials at the National Institutes of Health in the mid-1990s, and chaired the department of epidemiology at Greece’s University of Ioannina School of Medicine. But at NIH Ioannidis had an epiphany. “Positive” drug trials, which find that a treatment is effective, and “negative” trials, in which a drug fails, take the same amount of time to conduct. “But negative trials took an extra two to four years to be published,” he noticed. “Negative results sit in a file drawer, or the trial keeps going in hopes the results turn positive.” With billions of dollars on the line, companies are loath to declare a new drug ineffective. As a result of the lag in publishing negative studies, patients receive a treatment that is actually ineffective. That made Ioannidis wonder, how many biomedical studies are wrong?

His answer, in a 2005 paper: “the majority.”

via Why Almost Everything You Hear About Medicine Is Wrong – Newsweek.

Time travel using entanglement

Recently, it has been shown that the massless quantum vacuum state contains entanglement between timelike separated regions of spacetime, in addition to the entanglement between the spacelike separated regions usually considered. Here, we show that timelike entanglement can be extracted from the Minkowski vacuum and converted into ordinary entanglement between two inertial, two-state detectors at the same spatial location — one coupled to the field in the past and the other coupled to the field in the future. The procedure used here demonstrates a clear time correlation as a requirement for extraction, e.g. if the past detector was active at a quarter to 12:00, then the future detector must wait to become active at precisely a quarter past 12:00 in order to achieve entanglement.

via [1101.2565] Extraction of timelike entanglement from the quantum vacuum.

Antimatter created by Thunderstorms

Scientists using NASA’s Fermi Gamma-ray Space Telescope have detected beams of antimatter produced above thunderstorms on Earth, a phenomenon never seen before.

Scientists think the antimatter particles were formed in a terrestrial gamma-ray flash TGF, a brief burst produced inside thunderstorms and shown to be associated with lightning. It is estimated that about 500 TGFs occur daily worldwide, but most go undetected.

“These signals are the first direct evidence that thunderstorms make antimatter particle beams,” said Michael Briggs, a member of Fermi’s Gamma-ray Burst Monitor GBM team at the University of Alabama in Huntsville UAH. He presented the findings Monday, during a news briefing at the American Astronomical Society meeting in Seattle.

via NASA – NASA’s Fermi Catches Thunderstorms Hurling Antimatter into Space.

Life Built With Arsenic – life will never be the same!

NASA-funded astrobiology research has changed the fundamental knowledge about what comprises all known life on Earth.

Researchers conducting tests in the harsh environment of Mono Lake in California have discovered the first known microorganism on Earth able to thrive and reproduce using the toxic chemical arsenic. The microorganism substitutes arsenic for phosphorus in its cell components.

“The definition of life has just expanded,” said Ed Weiler, NASA’s associate administrator for the Science Mission Directorate at the agency’s Headquarters in Washington. “As we pursue our efforts to seek signs of life in the solar system, we have to think more broadly, more diversely and consider life as we do not know it.”

This finding of an alternative biochemistry makeup will alter biology textbooks and expand the scope of the search for life beyond Earth. The research is published in this week’s edition of Science Express.

Carbon, hydrogen, nitrogen, oxygen, phosphorus and sulfur are the six basic building blocks of all known forms of life on Earth. Phosphorus is part of the chemical backbone of DNA and RNA, the structures that carry genetic instructions for life, and is considered an essential element for all living cells.

Phosphorus is a central component of the energy-carrying molecule in all cells (adenosine triphosphate) and also the phospholipids that form all cell membranes. Arsenic, which is chemically similar to phosphorus, is poisonous for most life on Earth. Arsenic disrupts metabolic pathways because chemically it behaves similarly to phosphate.

“We know that some microbes can breathe arsenic, but what we’ve found is a microbe doing something new — building parts of itself out of arsenic,” said Felisa Wolfe-Simon, a NASA Astrobiology Research Fellow in residence at the U.S. Geological Survey in Menlo Park, Calif., and the research team’s lead scientist. “If something here on Earth can do something so unexpected, what else can life do that we haven’t seen yet?”

via NASA – NASA-Funded Research Discovers Life Built With Toxic Chemical.

Partial reversal of aging achieved in mice

“When we flipped the telomerase switch on and looked a month later, the brains had largely returned to normal,” said DePinho. More newborn nerve cells were observed, and the fatty myelin sheaths around nerve cells — which had become thinned in the aged animals — increased in diameter. In addition, the increase in telomerase revitalized slumbering brain stem cells so they could produce new neurons.

To show that all this new activity actually caused functional improvements, the scientists tested the mice’s ability to avoid a certain area where they detected unpleasant odors that they associated with danger, such as scents of predators or rotten food. They had lost that survival skill as their olfactory nerve cells atrophied, but after the telomerase boost, those nerves regenerated and the mice regained their crucial sense of smell.

“One of the most amazing changes was in the animals’ testes, which were essentially barren as aging caused the death and elimination of sperm cells,” recounted DePinho. “When we restored telomerase, the testes produced new sperm cells, and the animals’ fecundity was improved — their mates gave birth to larger litters.”

The telomerase boost also lengthened the rodents’ life spans compared to their untreated counterparts — but they did not live longer than normal mice, said the researchers.

via Partial reversal of aging achieved in mice | Harvard Gazette.

Disinfectant using light

The technology decontaminates the air and exposed surfaces by bathing them in a narrow spectrum of visible-light wavelengths, known as HINS-light.

Clinical trials at Glasgow Royal Infirmary have shown that the HINS-light Environmental Decontamination System provides significantly greater reductions of bacterial pathogens in the hospital environment than can be achieved by cleaning and disinfection alone, providing a huge step forward in hospitals’ ability to prevent the spread of infection.

This novel decontamination technology was discovered and developed by a multidisciplinary team of experts, Professor Scott MacGregor (Electrical Engineer), Professor John Anderson and Dr Michelle Maclean (Microbiologists) and Professor Gerry Woolsey (Optical Physicist.)

Professor Anderson said: “The technology kills pathogens but is harmless to patients and staff, which means for the first time, hospitals can continuously disinfect wards and isolation rooms.

“The system works by using a narrow spectrum of visible-light wavelengths to excite molecules contained within bacteria. This in turn produces highly reactive chemical species that are lethal to bacteria such as meticillin-resistant Staphylococcus aureus, or MRSA, and Clostridium difficile, known as C.diff.”

via News Releases – University of Strathclyde.

Twitter mood predicts the stock market

Behavioral economics tells us that emotions can profoundly affect individual behavior and decision-making. Does this also apply to societies at large, i.e., can societies experience mood states that affect their collective decision making? By extension is the public mood correlated or even predictive of economic indicators? Here we investigate whether measurements of collective mood states derived from large-scale Twitter feeds are correlated to the value of the Dow Jones Industrial Average (DJIA) over time. We analyze the text content of daily Twitter feeds by two mood tracking tools, namely OpinionFinder that measures positive vs. negative mood and Google-Profile of Mood States (GPOMS) that measures mood in terms of 6 dimensions (Calm, Alert, Sure, Vital, Kind, and Happy). We cross-validate the resulting mood time series by comparing their ability to detect the public’s response to the presidential election and Thanksgiving day in 2008. A Granger causality analysis and a Self-Organizing Fuzzy Neural Network are then used to investigate the hypothesis that public mood states, as measured by the OpinionFinder and GPOMS mood time series, are predictive of changes in DJIA closing values. Our results indicate that the accuracy of DJIA predictions can be significantly improved by the inclusion of specific public mood dimensions but not others. We find an accuracy of 87.6% in predicting the daily up and down changes in the closing values of the DJIA and a reduction of the Mean Average Percentage Error by more than 6%.

via [1010.3003] Twitter mood predicts the stock market.

Interesting: the OpinionFinder (which is itself examined here and GPOMS could be used to find other mood causalities…

Yes – Opinion Mining and sentiment analysis has a look at this

There’s a whole world of Sentiment Analysis out there!

Drinking water, from sunshine

Led by Steven Dubowsky, a professor in both the Department of Mechanical Engineering and the Department of Aeronautics and Astronautics, and graduate students Amy Bilton and Leah Kelley, the group built a small prototype of the system last spring to test algorithms they had developed to run it. They have since demonstrated that the prototype is capable of producing 80 gallons of water a day in a variety of weather conditions. They estimate that a larger version of the unit, which would cost about $8,000 to construct, could provide about 1,000 gallons of water per day. Dubowsky and his students also estimate that one C-130 cargo airplane could transport two dozen desalination units — enough to provide water for 10,000 people.

via In The World: Drinking water, from sunshine.

Another clever thing is that it uses hardly any external power at all.

Electrodes translate brain waves into words – latimes.com

In a first step toward helping severely paralyzed people communicate more easily, Utah researchers have shown that it is possible to translate recorded brain waves into words, using a grid of electrodes placed directly on the brain.

Although they have only done it with one person and individual words can only be identified with accuracy in tests 50% of the time, the study reported Tuesday provides a ray of hope for people who can now communicate only by blinking, or wiggling a fingertip.

“This is quite a simple technology … based on devices that have been used in humans for 50 years now,” said bioengineer Bradley Greger of the University of Utah, the lead author of a report in the Journal of Neuroengineering.

via Electrodes translate brain waves into words – latimes.com.

Thermosphere collapses and nobody knows why

An upper layer of Earth s atmosphere recently collapsed in an unexpectedly large contraction the sheer size of which has scientists scratching their heads NASA announced Thursday.

The layer of gas – called the thermosphere – is now rebounding again. This type of collapse is not rare but its magnitude shocked scientists.

“This is the biggest contraction of the thermosphere in at least 43 years ” said John Emmert of the Naval Research Lab lead author of a paper announcing the finding in the June 19 issue of the journal Geophysical Research Letters. “It s a Space Age record.”

The collapse occurred during a period of relative solar inactivity – called a solar minimum from 2008 to 2009. These minimums are known to cool and contract the thermosphere however the recent collapse was two to three times greater than low solar activity could explain.

“Something is going on that we do not understand ” Emmert said.

via SPACE.com — Record Collapse of Earth’s Upper Atmosphere Puzzles Scientists.

People ignore facts, opinions are based on beliefs

Not only that, but presenting people with facts can entrench them further in their beliefs. People willfully ignore facts that don’t correspond to their opinions.

“This bodes ill for a democracy, because most voters — the people making decisions about how the country runs — aren’t blank slates. They already have beliefs, and a set of facts lodged in their minds. The problem is that sometimes the things they think they know are objectively, provably false. And in the presence of the correct information, such people react very, very differently than the merely uninformed. Instead of changing their minds to reflect the correct information, they can entrench themselves even deeper.”

A very good article

How facts backfire – The Boston Globe.

Incidental Haptic Sensations Influence Social Judgments and Decisions — Ackerman et al. 328 (5986): 1712 — Science

Touch is both the first sense to develop and a critical means of information acquisition and environmental manipulation. Physical touch experiences may create an ontological scaffold for the development of intrapersonal and interpersonal conceptual and metaphorical knowledge, as well as a springboard for the application of this knowledge. In six experiments, holding heavy or light clipboards, solving rough or smooth puzzles, and touching hard or soft objects nonconsciously influenced impressions and decisions formed about unrelated people and situations. Among other effects, heavy objects made job candidates appear more important, rough objects made social interactions appear more difficult, and hard objects increased rigidity in negotiations. Basic tactile sensations are thus shown to influence higher social cognitive processing in dimension-specific and metaphor-specific ways.

via Incidental Haptic Sensations Influence Social Judgments and Decisions — Ackerman et al. 328 (5986): 1712 — Science.

Electrical network frequency analysis

The UK Metropolitan Police has been recording the frequency variations on the National Grid every second and a half for the past five years. When examining recordings, scientists are able to match the variations in the recordings with the database and establish exactly when the recording was made. If there are multiple matches, the recording was edited, and scientists can find out when. The process takes about 10 minutes.

via Met lab claims ‘biggest breakthrough since Watergate’ • The Register.

Animals That Live Without Oxygen discovered

Scientists have found the first multicellular animals that apparently live entirely without oxygen. The creatures reside deep in one of the harshest environments on earth: the Mediterranean Ocean's L'Atalante basin, which contains salt brine so dense that it doesn't mix with the oxygen-containing waters above. Previous samples taken from the water and sediments in the basin showed that single-celled life was present, but a new study published this week in BMC Biology has identified multi-cellular animals that apparently live and reproduce in the sediments under the salt brine. Italian and Danish researchers describe three new species of tiny animals called Loricifera.

via ScienceShot: Animals That Live Without Oxygen – ScienceNOW.