I don’t know if anyone else has noticed this but everything seems to be going down the tubes quite fast. And not fun tubes, like at a waterpark. The “ending in shit” kind. The issues are complicated, the reasons diverse, but there are a few culprits who have been making themselves extremely visible.

Alongside those holding political office, tech gragillionnaires (I had to invent a new number) like Elon Musk and Mark Zuckerberg obviously wield huge global influence with their computers and numbers and whatnot. There has been a lot written about them and there will be more, as they continue to shape the world and win favour with Donald Trump. Big, scary, probably ruinous things lie ahead. But I’m here to discuss the smaller part. The insult to injury, the sprinkling of salt in the wound.

Whether I am engaging with the news, or with Musk tweeting constantly like a man with no job or friends, or with Zuckerberg sending out weird videos and appearing on Rogan, I am in pain. Not just because I don’t like what they are doing but because they are so incredibly, painfully cringe.

I knew that one day we might have to watch as capitalism and greed and bigotry led to a world where powerful men, deserving or not, would burn it all down. What I didn’t expect, and don’t think I could have foreseen, is how incredibly cringe it would all be. I have been prepared for evil, for greed, for cruelty, for injustice – but I did not anticipate that the people in power would also be such huge losers.

[…]

Musk’s clear desperation, even as he holds this much wealth and power in his hands, to be thought of as cool. There are endless examples of him embarrassing himself while attempting to be funny or to gain respect. Unfortunately, while you may be able to buy power, it’s impossible to buy a good personality. Watching his Nigel-no-friends attempts to be popular, his endless pathetic tweets that read as though they come from the brain of an 11-year-old poser, has made me start to believe we should bring back bullying. If yet another humiliating report in the last couple of days is to be believed, he appears even to have lost the respect of some of his gamer audience, who the report claims suspect that he may have been lying about his achievements in hardcore gaming (cursed sentence).

Zuckerberg is a different kind of cringe – but cringe all the same. His cringe moments drip through more sparingly but, when they do, my body tries to turn inside out at my bellybutton. His physical makeover for Maga reasons, performing music because no one will stop him, trying to look cool on a surfboard – all these are extremely difficult to watch. He has been trying to suck up to Trump, going on Joe Rogan’s show to say society has been “neutered” and companies need “more masculine energy”.

Putting on what is clearly a bro disguise to join the boys’ club and sit at the big boy table – it should feel humiliating. This came as Zuckerberg rolled back hate speech and factchecking rules at Meta, in a clear swerve to the right before Trump’s inauguration. What could be more masculine and cool than selling out vulnerable communities and women to impress the alpha male?

Climate crises keep coming, genocides continue, women keep getting murdered, art is being strangled to death by AI, bigotry is on the rise, social progress is being rolled back … AND these men insist on being cringe? It’s a rotten cherry on top. This combination of evil and embarrassment is a unique horror, one that science fiction has failed to prepare us for. The second-hand embarrassment we have to endure gets even more potent when combined with other modern influences on young men, like Jordan Peterson and Andrew Tate.

Peterson is a big voice in men’s rights – well, a small Kermit’s voice in men’s rights – and he’s also an embarrassment. So much so that he has his own Know Your Meme page, which covers that time he reportedly retweeted an image from a fetish film, apparently believing it was a Chinese communist “sperm extraction” facility. He deleted it shortly afterwards.

Tate is facing human trafficking charges but rose to fame as a voice for young men, a misogynist in bad outfits who does really cool things like smoking cigars, wearing sunnies inside and trying to drag human rights back 100 years.

Living your life to impress other men by hating women is one of the most embarrassing things I can imagine. Looking up to any of these men for how to live your life is even sadder.

I’ve worked hard to keep these kinds of men out of my personal life, to keep them away from me, out of my goddamn sight. Now they are in my face daily, not only influencing the world for the worse but making me nauseous at how uncool and pathetic they are, on top of their other sins. It’s too much, I can’t take it, there needs to be a change.

It’s time for us to start getting revenge on the nerds.

Source: I knew one day I’d have to watch powerful men burn the world down – I just didn’t expect them to be such losers | Rebecca Shaw | The Guardian

Meta isn’t stopping at moderation changes. According to both Axios and The New York Times, the company is also pulling the plug on diversity, equity and inclusion (DEI) initiatives. That includes removing diversity hiring goals, eliminating the chief diversity officer position and no longer prioritizing minority-owned businesses as vendors, per The Times‘ reporting.

When asked to comment on ending DEI initiatives, Meta confirmed the reporting was accurate.

Internally, the company is apparently pinning the decision on a shifting “legal and policy landscape,” according to a memo to employees Axios acquired.

“The Supreme Court of the United States has recently made decisions signaling a shift in how courts will approach DEI,” Janelle Gale, Meta’s VP of Human Resources says in the memo. “The term ‘DEI’ has also become charged, in part because it is understood by some as a practice that suggests preferential treatment of some groups over others.”

The current Supreme Court is not exactly friendly towards systemic attempts to address issues of race, gender and sexuality, but in the context of Meta’s other recent changes, it seems like there’s more going on than the company being afraid of a possible lawsuit.

At the same time that Mark Zuckerberg was announcing that Meta was abandoning third-party fact checking and changing what kind of speech it allows on its platform, 404 Media reports that the company removed the Trans and Non-binary themes from Messenger, and posts it made announcing them. The company also added Trump supporter and UFC CEO Dana White to its board this week, a confirmation of Zuckerberg’s continuing UFC fandom but also a signal that it’s eager to listen to conservative voices. It all seems to add up to less of a reaction to the current climate and more like the way people in charge want to be doing business going forward.

Source: Meta’s right-wing reinvention also includes an end to DEI programs and trans Messenger themes

Meta is abandoning the use of independent fact checkers on Facebook and Instagram, replacing them with X-style “community notes” where commenting on the accuracy of posts is left to users.

In a video posted alongside a blog post by the company on Tuesday, chief executive Mark Zuckerberg said third-party moderators were “too politically biased” and it was “time to get back to our roots around free expression”.

The move comes as Zuckerberg and other tech executives seek to improve relations with US President-elect Donald Trump before he takes office later this month.

Trump and his Republican allies have criticised Meta for its fact-checking policy, calling it censorship of right-wing voices.

Speaking after the changes were announced, Trump told a news conference he was impressed by Zuckerberg’s decision and that Meta had “come a long way”.

Asked whether Zuckerberg was “directly responding” to threats Trump had made to him in the past, the incoming US president responded: “Probably”.

[…]

Source: Meta to replace ‘biased’ fact-checkers with moderation by users

So apart from donating money to the Oligarchy, now there will be a kind of “free speech” where Trump amigo’s and nutjobs can cry all they like whilst silencing actual intelligence. I wonder how fast people will leave FB for Bluesky.

[…] In 2022, Doctorow coined the word “enshittification”, which has just been crowned Macquarie Dictionary’s word of the year. The dictionary defined the word as follows.

“The gradual deterioration of a service or product brought about by a reduction in the quality of service provided, especially of an online platform, and as a consequence of profit-seeking.”

Social media users, if they don’t know the word, will viscerally understand the concept, the way trolls and extremists and bullshitters and the criminally vacuous have overtaken the platforms.

[…]

Doctorow wrote that this decay was a three-stage process.

“First, platforms are good to their users; then they abuse their users to make things better for their business customers; finally, they abuse those business customers to claw back all the value for themselves,” he wrote.

[…]

Source: ‘What many of us feel’: why ‘enshittification’ is Macquarie Dictionary’s word of the year | Language | The Guardian

Following a public vote in which more than 37,000 people had their say, we’re pleased to announce that the Oxford Word of the Year for 2024 is ‘brain rot’.

Our language experts created a shortlist of six words to reflect the moods and conversations that have helped shape the past year. After two weeks of public voting and widespread conversation, our experts came together to consider the public’s input, voting results, and our language data, before declaring ‘brain rot’ as the definitive Word of the Year for 2024.

[…]

‘Brain rot’ is defined as “the supposed deterioration of a person’s mental or intellectual state, especially viewed as the result of overconsumption of material (now particularly online content) considered to be trivial or unchallenging. Also: something characterized as likely to lead to such deterioration”.

Our experts noticed that ‘brain rot’ gained new prominence this year as a term used to capture concerns about the impact of consuming excessive amounts of low-quality online content, especially on social media. The term increased in usage frequency by 230% between 2023 and 2024.

The first recorded use of ‘brain rot’ was found in 1854 in Henry David Thoreau’s book Walden, which reports his experiences of living a simple lifestyle in the natural world. As part of his conclusions, Thoreau criticizes society’s tendency to devalue complex ideas, or those that can be interpreted in multiple ways, in favour of simple ones, and sees this as indicative of a general decline in mental and intellectual effort: “While England endeavours to cure the potato rot, will not any endeavour to cure the brain-rot – which prevails so much more widely and fatally?”

The term has taken on new significance in the digital age, especially over the past 12 months. Initially gaining traction on social media platform—particularly on TikTok among Gen Z and Gen Alpha communities—’brain rot’ is now seeing more widespread use, such as in mainstream journalism, amidst societal concerns about the negative impact of overconsuming online content.

[…]

Find out more about our Word of the Year shortlist for 2024

Source: ‘Brain rot’ named Oxford Word of the Year 2024

The oxford list contained brain rot, demure, dynamic pricing, lore, romantasy and slop. No ideas how they got to this list, maybe they didn’t want anything with a swear word in it? Maybe they were afraid of offending anyone? Well, it definitely shows the enshittification of the Oxford word list.

Education should promote deep inquiry and individual autonomy, but often, it has been used as a vehicle for indoctrination. That’s what Agustina S. Paglayan, a UC San Diego assistant professor of political science in the School of Social Sciences and the School of Global Policy and Strategy, argues in her new book, “Raised to Obey: The Rise and Spread of Mass Education.”

Paglayan uses evidence from both the past and the present to argue that schools around the world are failing to cultivate critical thinking skills in students—and that these institutions are actually designed to promote conformity. The book has already been praised by 2024 Nobel Laureate James Robinson as “path-breaking and iconoclastic,” and Paglayan’s perspective promises to open new debates in politics and education.

[…]

Primary education was created well before the arrival of democracy, sometimes under oligarchic or absolutist regimes. That made me doubt the conventional wisdom that democracy was the main driver behind the expansion of primary education.

[…]

the majority of children in most countries gained access to primary schooling long before democracy took root. This is true not only for countries like China or Russia, but also for most Western countries.

[…]

Mass education was really crafted as a clever system to instill obedience to the state and its laws. Schools used rewards and punishments to enforce rules, moral education dominated the curriculum and even basic reading and writing exercises taught compliance, like when students were asked to spell words like “duty” and “order.”

School routines—following schedules, marching in lines, asking permission—all reinforced discipline. The entire system, from teacher training to school inspections, aimed to create citizens who wouldn’t question authority or disrupt the status quo.

Governments saw schools as essential to maintaining internal security, viewing primary education less as a means to reduce poverty or promote industrialization than as a way to prevent social disorder.

The timing of when primary education expanded is revealing: It often followed episodes of mass violence or rebellion. Prussia created its public primary education system after peasant revolts, Massachusetts passed its first education law after Shays’ Rebellion in the late 1780s, and Colombia accelerated education access after La Violencia, which lasted from 1948 to 1958.

In each case, internal threats heightened elites’ anxieties about mass violence and the breakdown of social order, intensifying their fear of the masses and driving them to support mass education to transform “unruly” and “savage” children into compliant, law-abiding citizens

[…]

The anti-critical race theory curriculum reforms and textbook bans of the last four years and Donald Trump’s recent announcement that he’ll promote “patriotic education” and prohibit “radicalized” ideas from entering the classroom—while these may sound unprecedented—are no anomaly. They fit the cross-national pattern I uncover in the book. For the last 200 years, politicians in Western societies have become especially interested in teaching children that the status quo is okay following episodes of mass uprising against existing institutions.

This is precisely what has happened in the U.S. The Black Lives Matter protests of summer 2020 made Republican politicians especially anxious about institutional reform. Then-President Trump responded by setting up the 1776 Commission to strengthen patriotic education and to prevent children’s exposure to the concept of institutionalized racism. Republican state legislators and governors followed suit with curriculum reforms in red states, and the president-elect has made it clear he intends to extend these efforts to blue states too.

A key lesson from my book is that curriculum reforms tend to stick around for a very long time, outlasting the government that adopted them. It’s important for people to be aware of this fact. If you care about the content of education, now is the time to become involved in shaping the curriculum.

[…]

Roughly a third of children remain unable to read a simple sentence even after four years of schooling. This deficit of skills disproportionately affects low-income students. It exists in both developing and developed countries, and the problem has been recognized by numerous international organizations.

In the U.S., for example, children from high-income families enter kindergarten with much stronger literacy skills than low-income children, and K-12 schools fail to close that gap. I argue that these problems are rooted in the very origins of modern education systems, which were not designed to promote skills or equity.

[…]

For public schools to live up to their promise, education systems need to be deeply transformed. The systems we have today were inherited from a time when promoting compliance was the goal, a time when critical thinking was considered dangerous. In the 21st century, critical thinking skills are essential to safeguard liberal democracy, to get a good job and to remain internationally competitive.

The task ahead is not about fine-tuning the specific subjects taught. The challenge is to reimagine K-12 public schools as spaces that genuinely foster critical inquiry and creative, independent thought.

[…]

Source: Q&A: Mass education was designed to quash critical thinking, argues researcher

Tiny fragments of microplastics are making their way deep inside our bodies in concerning quantities, significantly through our food and drink.

Scientists have recently found a simple and effective means of removing them from water.

[…]

In some cases, up to 90 percent of the NMPs were removed by the boiling and filtering process, though the effectiveness varied based on the type of water.

Of course the big benefit is that most people can do it using what they already have in their kitchen.

“This simple boiling water strategy can ‘decontaminate’ NMPs from household tap water and has the potential for harmlessly alleviating human intake of NMPs through water consumption,” write biomedical engineer Zimin Yu from Guangzhou Medical University and colleagues.

A greater concentration of NMPs was removed from samples of hard tap water, which naturally forms a build-up of limescale (or calcium carbonate) as it is heated.

Commonly seen inside kitchen kettles, the chalky substance forms on the plastic’s surface as changes in temperature force the calcium carbonate out of solution, effectively trapping the plastic fragments in a crust.

[…]

Even in soft water, where less calcium carbonate is dissolved, roughly a quarter of the NMPs were snagged from the water.

[…]

The team behind this latest study wants to see more research into how boiled water could keep artificial materials out of our bodies – and perhaps counter some of the alarming effects of microplastics that are emerging.

[…]

Source: There’s a Surprisingly Easy Way to Remove Microplastics From Drinking Water

“Habits play a central role in our daily lives, from making that first cup of coffee in the morning, to the route we take to work, and the routine we follow to prepare for bed. Our research reveals why these automatic behaviours are so powerful — and how we can harness our brain’s mechanisms to change them. We bring together decades of research from laboratory studies as well as research from real-world settings to get a picture of how habits work in the human brain.”

Our habits are shaped by two brain systems — one that triggers automatic responses to familiar cues and another that enables goal-directed control. So for example, scrolling through social media when you are bored is the result of automatic response system, and putting your phone away to focus on work is enabled by the goal-directed control brain system.

It is precisely the imbalance between these two brain systems that is key. The research found that such imbalance can lead to everyday action slips such as inadvertently entering an old password instead of the current one. In more extreme cases, Professor Gillan’s research has shown that it can even contribute to compulsive behaviours seen in conditions such as obsessive compulsivedisorder, substance use disorders, and eating disorders.

Habits happen when automatic responses outweigh our ability to consciously control them. Good and bad habits are two sides of the same coin — both arise when automatic responses overpower goal-directed control. By understanding this dynamic, we can start to use it to our own advantage, to both make and break habits.

The new framework describes several factors that can influence the balance between automatic responses and goal-directed control:

• Repetition and reinforcement are essential to making our habits stick. Repeating a behaviour builds strong associations between environmental cues and responses, while rewarding the behaviour makes it more likely to be repeated. In leveraging the same mechanism to break habits, we can replace old behaviours with new ones to create competing automatic responses.
• The environment also plays a key role in habit change. Adjusting your surroundings can help; making desired behaviours easier to access encourages good habits, while removing cues that trigger unwanted behaviour disrupts bad habits.
• Knowing how to engage your own goal-directed system can help strengthen and weaken habits. Disengaging from effortful control, such as listening to a podcast while exercising, accelerates habit formation. However, stress, time pressure, and fatigue can trigger a return to old patterns, so staying mindful and intentional is key when trying to break them.

Dr Buabang explains, “Our research provides a new ‘playbook’ for behaviour change by connecting brain science with practical, real-world applications. We include effective strategies like implementation intentions, so-called, if-then plans (“if situation X occurs, then I will do Y”), and also integrate clinical interventions such as exposure therapy, habit reversal therapy, contingency management, and brain stimulation. It is important that our framework not only captures existing interventions but also provides targets for the development of new ones.”

This research also opens new possibilities for personalising treatments based on how different people form and break habits, making interventions more effective.

Source: Researchers discover new cognitive blueprint for making and breaking habits | ScienceDaily

Formula 1 drivers have urged the sport’s governing body to treat them like adults after Max Verstappen and Charles Leclerc were punished for swearing.

The Grand Prix Drivers’ Association (GPDA) has also criticised FIA president Mohammed Ben Sulayem for his “tone and language” when addressing the topic.

An open letter from the GPDA said: “There is a difference between swearing intended to insult others and more casual swearing, such as you might use to describe bad weather, or indeed an inanimate object such as an F1 car, or a driving situation.

“We urge the FIA president to consider his own tone and language when talking to our member drivers, or indeed about them, whether in a public forum or otherwise.

“Further, our members are adults. They do not need to be given instructions by the media about matters as trivial as the wearing of jewellery or underpants.”

[…]

Source: Formula 1 drivers ask FIA to treat them like adults after swearing punishments – BBC Sport

Formula 1 has seen a crackdown on explicit language—the latest in a string of regulations enforced by the FIA in recent seasons. From restrictions on jewelry to mandates on underwear, F1’s governing body, the FIA, has implemented rules that some drivers feel have strayed too far into “trivial” territory.

In the wake of penalties imposed on drivers like Max Verstappen and Charles Leclerc for swearing, drivers are openly questioning the FIA’s governance, urging the organization to treat them as professionals and adults. They’re also calling for greater transparency, asking pointedly, “How are the FIA’s financial fines allocated and where are the funds spent?”

[…]

At the Singapore Grand Prix press conference, Max Verstappen used a swear word to bluntly describe what the car felt like, his frustrations deep. Within a day, the FIA summoned him, citing a violation of the International Sporting Code, ultimately imposing a community service penalty.

[…]

Even Lewis Hamilton weighed in, saying Verstappen should refuse the community service requirement because his penalty was too harsh. “I think it’s a bit of a joke, to be honest,” said Hamilton. “This is the pinnacle of the sport. Mistakes are made…I certainly [wouldn’t] be doing it and I hope Max doesn’t do it,” said the Briton.

[…]

Most recently, Charles Leclerc also found himself in hot water after he swore during a press conference post-Mexican Grand Prix. The Monegasque apologized immediately after so was let off with a fine of €10,000, half of which will be suspended for a year and no community service.

[…]

Perhaps the move for stricter decorum in Formula 1 also has to do with wider broadcast decency standards. With Formula 1’s recent reportedly $90 million per year broadcast deal with ESPN, the sport is increasingly aligning with the United States’ strict media standards, where explicit language is heavily monitored—a move indicating that the sport is trying to align with American market demands and more conservative media norms.

[…]

Source: F1 Drivers Draw A Line: What’s Behind The FIA’s Swearing Crackdown?

Remember, the drivers voices are not broadcast real time and the swearing is usually bleeped out (which is disappointing as well)

[…] RSV vaccination provided approximately 80 percent protection against severe disease and hospitalization, Intensive Care Unit admission and death due to a respiratory infection as well as similar protection against less severe disease in adults who visited an emergency department but did not require hospitalization, ages 60 and older. Of this population, those ages 75 and older — were at highest risk of severe disease and were the most likely to be hospitalized.

[…]

In the U.S., respiratory disease season typically commences in late September or early October and continues through March or early April.

RSV affects the nose, throat and lungs, causing substantial illness and death among older adults during these seasonal epidemics. In years prior to the availability of an RSV vaccine, an estimated 60,000 to 160,000 RSV-associated hospitalizations and 6,000 to 10,000 RSV-associated deaths occurred annually among U.S. adults aged 65 years and older, according to the CDC.

[…]

Dr. Dixon added “Studies like this one are critical to understanding the effects of prevention techniques like vaccination. The annual cost of RSV hospitalization for adults in the U.S. is estimated to be between $1.2 and $5 billion. Preventing up to 80 percent of hospitalizations could result in major savings for consumers and the health system.”

[…]

Source: Big data, real world, multi-state study finds RSV vaccine highly effective in protecting older adults against severe disease, hospitalization and death | ScienceDaily

Scientists from Duke-NUS Medical School and the University of California, Santa Cruz, have discovered the secret to regulating our internal clock. They identified that this regulator sits right at the tail end of Casein Kinase 1 delta (CK1δ), a protein which acts as a pace setter for our internal biological clock or the natural 24-hour cycles that control sleep-wake patterns and other daily functions, known as circadian rhythm.

Published in the journal PNAS, their findings could pave the way for new approaches to treating disorders related to our body clock.

CK1δ regulates circadian rhythms by tagging other proteins involved in our biological clock to fine-tune the timing of these rhythms. In addition to modifying other proteins, CK1δ itself can be tagged, thereby altering its own ability to regulate the proteins involved in running the body’s internal clock.

[…]

“Our findings pinpoint to three specific sites on CK1δ’s tail where phosphate groups can attach, and these sites are crucial for controlling the protein’s activity. When these spots get tagged with a phosphate group, CK1δ becomes less active, which means it doesn’t influence our circadian rhythms as effectively. Using high-resolution analysis, we were able to pinpoint the exact sites involved — and that’s really exciting.”

[…]

We found that the δ1 tail interacts more extensively with the main part of the protein, leading to greater self-inhibition compared to δ2. This means that δ1 is more tightly regulated by its tail than δ2. When these sites are mutated or removed, δ1 becomes more active, which leads to changes in circadian rhythms. In contrast, δ2 does not have the same regulatory effect from its tail region.”

This discovery highlights how a small part of CK1δ can greatly influence its overall activity. This self-regulation is vital for keeping CK1δ activity balanced, which, in turn, helps regulate our circadian rhythms.

The study also addressed the wider implications of these findings. CK1δ plays a role in several important processes beyond circadian rhythms, including cell division, cancer development, and certain neurodegenerative diseases. By better understanding how CK1δ’s activity is regulated, scientists could open new avenues for treating not just circadian rhythm disorders but also a range of conditions.

[…]

“Regulating our internal clock goes beyond curing jet lag — it’s about improving sleep-quality, metabolism and overall health. This important discovery could potentially open new doors for treatments that could transform how we manage these essential aspects of our daily lives.”

The researchers plan to further investigate how real-world factors, such as diet and environmental changes, affect the tagging sites on CK1δ.

[…]

Story Source:

Materials provided by Duke-NUS Medical School. Note: Content may be edited for style and length.

---

Journal Reference:

1. Rachel L. Harold, Nikhil K. Tulsian, Rajesh Narasimamurthy, Noelle Yaitanes, Maria G. Ayala Hernandez, Hsiau-Wei Lee, Priya Crosby, Sarvind M. Tripathi, David M. Virshup, Carrie L. Partch. Isoform-specific C-terminal phosphorylation drives autoinhibition of Casein kinase 1. Proceedings of the National Academy of Sciences, 2024; 121 (41) DOI: 10.1073/pnas.2415567121

Source: Scientists discover a secret to regulating our body clock, offering new approach to end jet lag | ScienceDaily

• František Bartoš University of Amsterdam

DOI:

https://doi.org/10.15626/MP.2023.3987

Replicable and reliable research is essential for cumulative science and its applications in practice. This article examines the quality of research on dishonesty using a sample of 286 hand-coded test statistics from 99 articles. Z-curve analysis indicates a low expected replication rate, a high proportion of missing studies, and an inflated false discovery risk. Test of insufficient variance (TIVA) finds that 11/61 articles with multiple test statistics contain results that are “too-good-to-be-true”. Sensitivity analysis confirms the robustness of the findings. In conclusion, caution is advised when relying on or applying the existing literature on dishonesty.

Source: LnuOpen | Meta-Psychology

Countries with greater inequalities — whether economic, pollution or disease-based — exhibited older brain ages, according to a study published in Nature Medicine, involving the University of Surrey.

The pace at which the brain ages can vary significantly among individuals, leading to a gap between the estimated biological age of the brain and the chronological age (the actual number of years a person has lived). This difference may be affected by several things, such as environmental factors like pollution and social factors like income or health inequalities, especially in older people and those with dementia. Until now, it was unclear how these combined factors could either accelerate or delay brain ageing across diverse geographical populations.

In the study, a team of international researchers developed ways to measure brain ageing using advanced brain clocks based on deep learning of brain networks. This study involved a diverse dataset of 5,306 participants from 15 countries, including Latin American and Caribbean (LAC) nations and non-LAC countries. By analysing data from functional magnetic resonance imaging (fMRI) and electroencephalography (EEG), the researchers quantified brain age gaps in healthy individuals and those with neurodegenerative conditions such as mild cognitive impairment (MCI), Alzheimer’s disease, and frontotemporal lobe degeneration (FTLD).

Dr Daniel Abasolo, co-author of the study and Head of the Centre for Biomedical Engineering at the University of Surrey, said:

“Our research shows that in countries where inequality is higher, people’s brains tend to age faster, especially in areas of the brain most affected by ageing. We found that factors like socioeconomic inequality, air pollution, and the impact of diseases play a big role in this faster ageing process, particularly in poorer countries.”

Participants with a diagnosis of dementia, particularly Alzheimer’s disease, exhibited the most critical brain age gaps. The research also highlighted sex differences in brain ageing, with women in LAC countries showing greater brain age gaps, particularly in those with Alzheimer’s disease

[…]

Story Source:

Materials provided by University of Surrey. Note: Content may be edited for style and length.

---

Journal Reference:

1. Sebastian Moguilner, Sandra Baez, Hernan Hernandez, Joaquín Migeot, Agustina Legaz, Raul Gonzalez-Gomez, Francesca R. Farina, Pavel Prado, Jhosmary Cuadros, Enzo Tagliazucchi, Florencia Altschuler, Marcelo Adrián Maito, María E. Godoy, Josephine Cruzat, Pedro A. Valdes-Sosa, Francisco Lopera, John Fredy Ochoa-Gómez, Alfredis Gonzalez Hernandez, Jasmin Bonilla-Santos, Rodrigo A. Gonzalez-Montealegre, Renato Anghinah, Luís E. d’Almeida Manfrinati, Sol Fittipaldi, Vicente Medel, Daniela Olivares, Görsev G. Yener, Javier Escudero, Claudio Babiloni, Robert Whelan, Bahar Güntekin, Harun Yırıkoğulları, Hernando Santamaria-Garcia, Alberto Fernández Lucas, David Huepe, Gaetano Di Caterina, Marcio Soto-Añari, Agustina Birba, Agustin Sainz-Ballesteros, Carlos Coronel-Oliveros, Amanuel Yigezu, Eduar Herrera, Daniel Abasolo, Kerry Kilborn, Nicolás Rubido, Ruaridh A. Clark, Ruben Herzog, Deniz Yerlikaya, Kun Hu, Mario A. Parra, Pablo Reyes, Adolfo M. García, Diana L. Matallana, José Alberto Avila-Funes, Andrea Slachevsky, María I. Behrens, Nilton Custodio, Juan F. Cardona, Pablo Barttfeld, Ignacio L. Brusco, Martín A. Bruno, Ana L. Sosa Ortiz, Stefanie D. Pina-Escudero, Leonel T. Takada, Elisa Resende, Katherine L. Possin, Maira Okada de Oliveira, Alejandro Lopez-Valdes, Brain Lawlor, Ian H. Robertson, Kenneth S. Kosik, Claudia Duran-Aniotz, Victor Valcour, Jennifer S. Yokoyama, Bruce Miller, Agustin Ibanez. Brain clocks capture diversity and disparities in aging and dementia across geographically diverse populations. Nature Medicine, 2024; DOI: 10.1038/s41591-024-03209-x

Source: Your brain ages at different paces according to social and physical environments

Scientists have discovered a mutation in SARS-CoV-2, the virus that causes COVID-19, that plays a key role in its ability to infect the central nervous system. The findings may help scientists understand its neurological symptoms and the mystery of “long COVID,” and they could one day even lead to specific treatments to protect and clear the virus from the brain.

The new collaborative study between scientists at Northwestern University and the University of Illinois-Chicago uncovered a series of mutations in the SARS-CoV-2 spike protein (the outer part of the virus that helps it penetrate cells) that enhanced the virus’ ability to infect the brains of mice.

“Looking at the genomes of viruses found in the brain compared to the lung, we found that viruses with a specific deletion in spike were much better at infecting the brains of these animals,” said co-corresponding author Judd Hultquist, assistant professor of medicine (infectious diseases) and microbiology-immunology at Northwestern University Feinberg School of Medicine. “This was completely unexpected, but very exciting.”

[…]

In this study, researchers infected mice with SARS-CoV-2 and sequenced the genomes of viruses that replicated in the brain versus the lung. In the lung, the spike protein looked very similar to the virus used to infect the mice. In the brain, however, most viruses had a deletion or mutation in a critical region of spike that dictates how it enters a cell. When viruses with this deletion were used to directly infect the brains of mice, it was largely repaired when it traveled to the lungs.

“In order for the virus to traffic from the lung to the brain, it required changes in the spike protein that are already known to dictate how the virus gets into different types of cells,” Hultquist said. “We think this region of spike is a critical regulator of whether or not the virus gets into the brain, and it could have large implications for the treatment and management of neurological symptoms reported by COVID-19 patients.”

SARS-CoV-2 has long been associated with various neurological symptoms, such as the loss of smell and taste, “brain fog” and “long COVID.”

“It’s still not known if long COVID is caused by direct infection of cells in the brain or due to some adverse immune response that persists beyond the infection,” Hultquist said. “If it is caused by infection of cells in the central nervous system, our study suggests there may be specific treatments that could work better than others in clearing the virus from this compartment.”

[…]

Story Source:

Materials provided by Northwestern University. Note: Content may be edited for style and length.

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Journal Reference:

1. Jacob Class, Lacy M. Simons, Ramon Lorenzo-Redondo, Jazmin Galván Achi, Laura Cooper, Tanushree Dangi, Pablo Penaloza-MacMaster, Egon A. Ozer, Sarah E. Lutz, Lijun Rong, Judd F. Hultquist, Justin M. Richner. Evolution of SARS-CoV-2 in the murine central nervous system drives viral diversification. Nature Microbiology, 2024; DOI: 10.1038/s41564-024-01786-8

Source: Spike mutations help SARS-CoV-2 infect the brain | ScienceDaily

The elimination of damaged cell components is essential for the maintenance of the body’s tissues and organs. An international research team led by the University of Bonn has made significant findings on mechanisms for the clearing of cellular wastes, showing that strength training activates such mechanisms. The findings could form the basis for new therapies for heart failure and nerve diseases, and even afford benefits for manned space missions.

[…]

he protein BAG3 plays a critical role in the elimination of damaged components, identifying these and ensuring that they are enclosed by cellular membranes to form an “autophagosome.” Autophagosomes are like a garbage bag in which cellular waste is collected for later shredding and recycling. The research team led by Professor Jörg Höhfeld of the University of Bonn Institute of Cell Biology has shown that strength training activates BAG3 in the muscles.

[…]

“Impairment of the BAG3 system does indeed cause swiftly progressing muscle weakness in children as well as heart failure — one of the most common causes of death in industrialized Western nations,”

[…]

: “We now know what intensity level of strength training it takes to activate the BAG3 system, so we can optimize training programs for top athletes and help physical therapy patients build muscle better.”

[…]

“BAG3 is activated under mechanical force. But what happens if mechanical stimulation does not take place? In astronauts living in a weightless environment, for example, or immobilized intensive care patients on ventilation?” In such cases, the lack of mechanical stimulation rapidly leads to muscle atrophy, the cause of which Höhfeld ascribes at least in part to the non-activation of BAG3. Drugs developed to activate BAG3 might help in such situations, he believes

[…]

Story Source:

Materials provided by University of Bonn. Note: Content may be edited for style and length.

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Journal Reference:

1. Judith Ottensmeyer, Alessandra Esch, Henrique Baeta, Sandro Sieger, Yamini Gupta, Maximilian F. Rathmann, Andreas Jeschke, Daniel Jacko, Kirill Schaaf, Thorsten Schiffer, Bahareh Rahimi, Lukas Lövenich, Angela Sisto, Peter F.M. van der Ven, Dieter O. Fürst, Albert Haas, Wilhelm Bloch, Sebastian Gehlert, Bernd Hoffmann, Vincent Timmerman, Pitter F. Huesgen, Jörg Höhfeld. Force-induced dephosphorylation activates the cochaperone BAG3 to coordinate protein homeostasis and membrane traffic. Current Biology, 2024; DOI: 10.1016/j.cub.2024.07.088

Source: Strength training activates cellular waste disposal | ScienceDaily

New research from Oregon Health & Science University reveals negative health consequences for people who are overweight and ignore their body’s signals to sleep at night, with specific differences between men and women.

The study published this week in The Journal of Clinical Endocrinology & Metabolism.

“This study builds support for the importance of good sleep habits,” said lead author Brooke Shafer, Ph.D., a postdoctoral researcher in the Sleep, Chronobiology and Health Laboratory in the OHSU School of Nursing. “Sleep practices, like going to bed when you’re tired or setting aside your screen at night, can help to promote good overall health.”

The study recruited 30 people, split evenly between men and women. All had a body mass index above 25, which put them into an overweight or obese category.

[…]

Generally healthy participants contributed a saliva sample every 30 minutes until late in the night at a sleep lab on OHSU’s Marquam Hill campus to determine the time at which their body started naturally producing the hormone melatonin. Melatonin is generally understood to begin the process of falling asleep, and its onset varies with an individual’s internal biological clock.

Participants then went home and logged their sleep habits over the following seven days.

Researchers assessed the time difference between melatonin onset and average sleep timing for each participant, categorizing them into two groups: those who had a narrow window, with a short time duration between melatonin onset and sleep, and those with a wide window, with a longer duration between melatonin onset and sleep. A narrow window suggests someone who is staying awake too late for their internal body clock and is generally associated with poorer health outcomes.

The new study confirmed a variety of potentially harmful health measures in the group that went to sleep closer to melatonin onset.

It also found key differences between men and women. Men in this group had higher levels of belly fat and fatty triglycerides in the blood, and higher overall metabolic syndrome risk scores than the men who slept better. Women in this group had higher overall body fat percentage, glucose and resting heart rates.

[…]

Source: Good sleep habits important for overweight adults | ScienceDaily

Doctors have begun trialling the world’s first mRNA lung cancer vaccine in patients, as experts hailed its “groundbreaking” potential to save thousands of lives.

Lung cancer is the world’s leading cause of cancer death, accounting for about 1.8m deaths every year. Survival rates in those with advanced forms of the disease, where tumours have spread, are particularly poor.

Now experts are testing a new jab that instructs the body to hunt down and kill cancer cells – then prevents them ever coming back. Known as BNT116 and made by BioNTech, the vaccine is designed to treat non-small cell lung cancer (NSCLC), the most common form of the disease.

The phase 1 clinical trial, the first human study of BNT116, has launched across 34 research sites in seven countries: the UK, US, Germany, Hungary, Poland, Spain and Turkey.

[…]

The jab uses messenger RNA (mRNA), similar to Covid-19 vaccines, and works by presenting the immune system with tumour markers from NSCLC to prime the body to fight cancer cells expressing these markers.

The aim is to strengthen a person’s immune response to cancer while leaving healthy cells untouched, unlike chemotherapy.

[…]

six consecutive injections five minutes apart over 30 minutes at the National Institute for Health Research UCLH Clinical Research Facility on Tuesday.

Each jab contained different RNA strands. He will get the vaccine every week for six consecutive weeks, and then every three weeks for 54 weeks.

Lee said: “We hope adding this additional treatment will stop the cancer coming back because a lot of time for lung cancer patients, even after surgery and radiation, it does come back.”

[…]

Source: World-first lung cancer vaccine trials launched across seven countries | Lung cancer | The Guardian

[…] The paper also found the quantity of microplastics in brain samples from 2024 was about 50% higher from the total in samples that date to 2016, suggesting the concentration of microplastics found in human brains is rising at a similar rate to that found in the environment. Most of the organs came from the office of the medical investigator in Albuquerque, New Mexico, which investigates untimely or violent deaths.

[…]

Many other papers have found microplastics in the brains of other animal species, so it’s not entirely surprising the same could be true for humans

[…]

When it comes to these insidious particles, “the blood-brain barrier is not as protective as we’d like to think”

[…]

researchers say that individuals should try to reduce their exposure by avoiding the use of plastic in preparing food, especially when microwaving; drinking tap water instead of bottled water; and trying to prevent the accumulation of dust, which is contaminated with plastics. Some researchers advise eating less meat, especially processed products.

[…]

Source: Microplastics are infiltrating brain tissue, studies show: ‘There’s nowhere left untouched’ | Pollution | The Guardian

A new study that examined health data on 18 million people reveals higher incidence of mental illnesses for up to a year following severe COVID-19 in unvaccinated people. Vaccination appeared to mitigate the adverse effects of COVID-19 on mental illnesses. The University of Bristol-led study, published in JAMA Psychiatry today [21 August], investigated associations of COVID-19 with mental illnesses according to time since diagnosis and vaccination status.

[…]

Among the 18,648,606 adults in the cohort studied during the period before vaccination was available, the average age was 49 years, 50.2 per cent were female (9,363,710) and 1,012,335 adults had a confirmed COVID-19 diagnosis (recorded in testing data, by a GP, in hospital or in their death record).

The authors also studied a vaccinated cohort including 14,035,286 adults, of whom 866,469 had a confirmed COVID-19 diagnosis, with an average age of 53 years and 52.1 per cent female (7,308,556), and an unvaccinated cohort including 3,242,215 adults, of whom 149,745 had a confirmed COVID-19 diagnosis, with an average age of 35 years and 42.1 per cent female (1,363,401).

Using these data, the researchers compared the incidence of mental illnesses in people before and after a COVID-19 diagnosis, in each cohort. Mental illnesses included in this study comprised depression, serious mental illness, general anxiety, post-traumatic stress disorder, eating disorders, addiction, self-harm, and suicide.

The team found that the incidence of most of these conditions was higher one to four weeks after COVID-19 diagnosis, compared to the incidence before or without COVID-19. This elevation in the incidence of mental illnesses, was mainly seen after severe COVID-19 that led to hospitalisation and remained higher for up to a year following severe COVID-19 in unvaccinated people.

[…]

Story Source:

Materials provided by University of Bristol. Note: Content may be edited for style and length.

Source: Study of 18 million people finds increased mental illnesses incidence following severe COVID-19, especially in unvaccinated people | ScienceDaily