Dr. Bik is a microbiologist who has worked at Stanford University and for the Dutch National Institute for Health who is “blessed” with “what I’m told is a better-than-average ability to spot repeating patterns,” according to their new Op-Ed in the New York Times.

In 2014 they’d spotted the same photo “being used in two different papers to represent results from three entirely different experiments….” Although this was eight years ago, I distinctly recall how angry it made me. This was cheating, pure and simple. By editing an image to produce a desired result, a scientist can manufacture proof for a favored hypothesis, or create a signal out of noise. Scientists must rely on and build on one another’s work. Cheating is a transgression against everything that science should be. If scientific papers contain errors or — much worse — fraudulent data and fabricated imagery, other researchers are likely to waste time and grant money chasing theories based on made-up results…..

But were those duplicated images just an isolated case? With little clue about how big this would get, I began searching for suspicious figures in biomedical journals…. By day I went to my job in a lab at Stanford University, but I was soon spending every evening and most weekends looking for suspicious images. In 2016, I published an analysis of 20,621 peer-reviewed papers, discovering problematic images in no fewer than one in 25. Half of these appeared to have been manipulated deliberately — rotated, flipped, stretched or otherwise photoshopped. With a sense of unease about how much bad science might be in journals, I quit my full-time job in 2019 so that I could devote myself to finding and reporting more cases of scientific fraud.

Using my pattern-matching eyes and lots of caffeine, I have analyzed more than 100,000 papers since 2014 and found apparent image duplication in 4,800 and similar evidence of error, cheating or other ethical problems in an additional 1,700. I’ve reported 2,500 of these to their journals’ editors and — after learning the hard way that journals often do not respond to these cases — posted many of those papers along with 3,500 more to PubPeer, a website where scientific literature is discussed in public….

Unfortunately, many scientific journals and academic institutions are slow to respond to evidence of image manipulation — if they take action at all. So far, my work has resulted in 956 corrections and 923 retractions, but a majority of the papers I have reported to the journals remain unaddressed.
Manipulated images “raise questions about an entire line of research, which means potentially millions of dollars of wasted grant money and years of false hope for patients.” Part of the problem is that despite “peer review” at scientific journals, “peer review is unpaid and undervalued, and the system is based on a trusting, non-adversarial relationship. Peer review is not set up to detect fraud.”

But there’s other problems. Most of my fellow detectives remain anonymous, operating under pseudonyms such as Smut Clyde or Cheshire. Criticizing other scientists’ work is often not well received, and concerns about negative career consequences can prevent scientists from speaking out. Image problems I have reported under my full name have resulted in hateful messages, angry videos on social media sites and two lawsuit threats….

Things could be about to get even worse. Artificial intelligence might help detect duplicated data in research, but it can also be used to generate fake data. It is easy nowadays to produce fabricated photos or videos of events that never happened, and A.I.-generated images might have already started to poison the scientific literature. As A.I. technology develops, it will become significantly harder to distinguish fake from real.

Science needs to get serious about research fraud.
Among their proposed solutions? “Journals should pay the data detectives who find fatal errors or misconduct in published papers, similar to how tech companies pay bounties to computer security experts who find bugs in software.”

Source: ‘Science Has a Nasty Photoshopping Problem’ – Slashdot

Certain star clusters do not seem to be following current understandings of Isaac Newton’s laws of gravity, according to new research published on Wednesday.

The study, published in the Monthly Notices of the Royal Astronomical Society, analyzed open star clusters which are formed when thousands of stars are born in a short time period in a huge gas cloud.

As the stars are born, they blow away the remnants of the gas cloud, causing the cluster to expand and create a loose formation of dozens to thousands of stars held together by weak gravitational forces.

As the clusters dissolve, the stars accumulate on two “tidal tails:” one pulled behind the cluster and the other pushed forward.

“According to Newton’s laws of gravity, it’s a matter of chance in which of the tails a lost star ends up,” explains Dr. Jan Pflamm-Altenburg of the Helmholtz Institute of Radiation and Nuclear Physics at the University of Bonn. “So both tails should contain about the same number of stars. However, in our work we were able to prove for the first time that this is not true: In the clusters we studied, the front tail always contains significantly more stars nearby to the cluster than the rear tail.”

Dr. Tereza Jerabkova, a co-author of the paper, explained that it is very difficult to determine which stars belong to which tail.

“To do this, you have to look at the velocity, direction of motion and age of each of these objects,” said Jerabkova, who managed to develop a method to accurately count the stars for the first time using data from the European Space Agency’s Gaia mission.

The perks of a modified theory

When the researchers looked at the data, they found that it did not fit Newton’s law of gravity and instead fit better with an alternate theory called Modified Newtonian Dynamics (MOND).

“Put simply, according to MOND, stars can leave a cluster through two different doors,” explained Prof. Dr. Pavel Kroupa of the Helmholtz Institute of Radiation and Nuclear Physics. “One leads to the rear tidal tail, the other to the front. However, the first is much narrower than the second – so it’s less likely that a star will leave the cluster through it. Newton’s theory of gravity, on the other hand, predicts that both doors should be the same width.”

The researchers simulated the stellar distribution expected according to the MOND theory and found that it lined up well with what they observed in the data from the Gaia mission.

Dr. Ingo Thies, who played a key role in the simulations, explained that the researchers needed to rely on relatively simple computational methods in the study since currently there are no mathematical tools for more detailed analyses of the MOND theory.

The simulations also coincided with the Gaia data in terms of how long the star clusters typically survive, which is much shorter than would be expected according to Newton’s laws.

“This explains a mystery that has been known for a long time,” said Kroupa. “Namely, star clusters in nearby galaxies seem to be disappearing faster than they should.”

The MOND theory is controversial as modifications to Newton’s laws of gravity would have far-reaching consequences for other areas of physics as well, although they would solve many problems facing cosmology.

[…]

Source: Behavior of star clusters challenge Newton’s laws of gravity – The Jerusalem Post

Paper: Asymmetrical tidal tails of open star clusters: stars crossing their cluster’s práh^† challenge Newtonian gravitation

[…]

The finding, which researchers made by measuring the electrical fields around honeybee (apis mellifera) hives, reveals that bees can produce as much atmospheric electricity as a thunderstorm. This can play an important role in steering dust to shape unpredictable weather patterns; and their impact may even need to be included in future climate models.

Insects’ tiny bodies can pick up positive charge while they forage — either from the friction of air molecules against their rapidly beating wings (honeybees can flap their wings more than 230 times a second) or from landing onto electrically charged surfaces. But the effects of these tiny charges were previously assumed to be on a small scale. Now, a new study, published Oct. 24 in the journal iScience, shows that insects can generate a shocking amount of electricity.

[…]

To test whether honeybees produce sizable changes in the electric field of our atmosphere, the researchers placed an electric field monitor and a camera near the site of several honeybee colonies. In the 3 minutes that the insects flooded into the air, the researchers found that the potential gradient above the hives increased to 100 volts per meter. In other swarming events, the scientists measured the effect as high as 1,000 volts per meter, making the charge density of a large honeybee swarm roughly six times greater than electrified dust storms and eight times greater than a stormcloud.

The scientists also found that denser insect clouds meant bigger electrical fields — an observation that enabled them to model other swarming insects such as locusts and butterflies.

Locusts often swarm to “biblical scales,” the scientists said, creating thick clouds 460 square miles (1,191 square kilometers) in size and packing up to 80 million locusts into less than half a square mile (1.3 square km). The researchers’ model predicted that swarming locusts’ effect on the atmospheric electric field was staggering, generating densities of electric charge similar to those made by thunderstorms.

The researchers say it’s unlikely the insects are producing storms themselves, but even when potential gradients don’t meet the conditions to make lightning, they can still have other effects on the weather. Electric fields in the atmosphere can ionize particles of dust and pollutants, changing their movement in unpredictable ways. As dust can scatter sunlight, knowing how it moves and where it settles is important to understanding a region’s climate.

[…]

Source: Swarming bees may potentially change the weather, new study suggests | Live Science

plant machete

This installation enables a live plant to control a machete. plant machete has a control system that reads and utilizes the electrical noises found in a live philodendron. The system uses an open source micro-controller connected to the plant to read varying resistance signals across the plant’s leaves. Using custom software, these signals are mapped in real-time to the movements of the joints of the industrial robot holding a machete. In this way, the movements of the machete are determined based on input from the plant. Essentially the plant is the brain of the robot controlling the machete determining how it swings, jabs, slices and interacts in space.

Source: plant machete — David Bowen

When ice sheets melt, something strange and highly counterintuitive happens to sea levels.

It works basically like a seesaw. In the area close to where theses masses of glacial ice melt, ocean levels fall. Yet thousands of miles away, they actually rise. It largely happens because of the loss of a gravitational pull toward the ice sheet, causing the water to disperse away. The patterns have come to be known as sea level fingerprints since each melting glacier or ice sheet uniquely impacts sea level. Elements of the concept—which lies at the heart of the understanding that global sea levels don’t rise uniformly—have been around for over a century and modern sea level science has been built around it. But there’s long been a hitch to the widely accepted theory. A sea level fingerprint has never definitively been detected by researchers.

A team of scientists—led by Harvard alumna Sophie Coulson and featuring Harvard geophysicist Jerry X. Mitrovica—believe they have detected the first. The findings are described in a new study published Thursday in Science. The work validates almost a century of sea level science and helps solidify confidence in models predicting future sea level rise.

[…]

Sea level fingerprints have been notoriously difficult to detect because of the major fluctuations in ocean levels brought on by changing tides, currents, and winds. What makes it such a conundrum is that researchers are trying to detect millimeter level motions of the water and link them to melting glaciers thousands of miles away.

[…]

The new study uses newly released satellite data from a European marine monitoring agency that captures over 30 years of observations in the vicinity of the Greenland Ice Sheet and much of the ocean close to the middle of Greenland to capture the seesaw in ocean levels from the fingerprint.

The satellite data caught the eye of Mitrovica and colleague David Sandwell of the Scripps Institute of Oceanography. Typically, satellite records from this region had only extended up to the southern tip of Greenland, but in this new release the data reached ten degrees higher in latitude, allowing them to eyeball a potential hint of the seesaw caused by the fingerprint.

[…]

Coulson quickly collected three decades worth of the best observations she could find on ice height change within the Greenland Ice Sheet as well as reconstructions of glacier height change across the Canadian Arctic and Iceland. She combined these different datasets to create predictions of sea level change in the region from 1993 to 2019, which she then compared with the new satellite data. The fit was perfect. A one-to-one match that showed with more than 99.9% confidence that the pattern of sea level change revealed by the satellites is a fingerprint of the melting ice sheet.

[…]

Source: Researchers detect the first definitive proof of elusive sea level fingerprints

Tiny nets woven from DNA strands can ensnare the spike protein of the virus that causes COVID-19, lighting up the virus for a fast-yet-sensitive diagnostic test—and also impeding the virus from infecting cells, opening a new possible route to antiviral treatment, according to a new study.

Researchers at the University of Illinois Urbana-Champaign and collaborators demonstrated the DNA nets’ ability to detect and impede COVID-19 in human cell cultures in a paper published in the Journal of the American Chemical Society.

“This platform combines the sensitivity of PCR and the speed and low cost of antigen tests,” said study leader Xing Wang, a professor of bioengineering and of chemistry at Illinois. “We need tests like this for a couple of reasons. One is to prepare for the next pandemic. The other reason is to track ongoing viral epidemics—not only coronaviruses, but also other deadly and economically impactful viruses like HIV or influenza.”

DNA is best known for its genetic properties, but it also can be folded into custom nanoscale structures that can perform functions or specifically bind to other structures much like proteins do. The DNA nets the Illinois group developed were designed to bind to the coronavirus spike protein—the structure that sticks out from the surface of the virus and binds to receptors on human cells to infect them. Once bound, the nets give off a fluorescent signal that can be read by an inexpensive handheld device in about 10 minutes.

The researchers demonstrated that their DNA nets effectively targeted the spike protein and were able to detect the virus at very low levels, equivalent to the sensitivity of gold-standard PCR tests that can take a day or more to return results from a clinical lab.

The technique holds several advantages, Wang said. It does not need any special preparation or equipment, and can be performed at room temperature, so all a user would do is mix the sample with the solution and read it. The researchers estimated in their study that the method would cost $1.26 per test.

“Another advantage of this measure is that we can detect the entire virus, which is still infectious, and distinguish it from fragments that may not be infectious anymore,” Wang said. This not only gives patients and physicians better understanding of whether they are infectious, but it could greatly improve community-level modeling and tracking of active outbreaks, such as through wastewater.

In addition, the DNA nets inhibited the virus’s spread in live cell cultures, with the antiviral activity increasing with the size of the DNA net scaffold. This points to DNA structures’ potential as therapeutic agents, Wang said.

“I had this idea at the very beginning of the pandemic to build a platform for testing, but also for inhibition at the same time,” Wang said. “Lots of other groups working on inhibitors are trying to wrap up the entire virus, or the parts of the virus that provide access to antibodies. This is not good, because you want the body to form antibodies. With the hollow DNA net structures, antibodies can still access the virus.”

The DNA net platform can be adapted to other viruses, Wang said, and even multiplexed so that a single test could detect multiple viruses.

“We’re trying to develop a unified technology that can be used as a plug-and-play platform. We want to take advantage of DNA sensors’ high binding affinity, low limit of detection, low cost and rapid preparation,” Wang said.

The paper is titled “Net-shaped DNA nanostructures designed for rapid/sensitive detection and potential inhibition of the SARS-CoV-2 virus.”

---

More information: Neha Chauhan et al, Net-Shaped DNA Nanostructures Designed for Rapid/Sensitive Detection and Potential Inhibition of the SARS-CoV-2 Virus, Journal of the American Chemical Society (2022). DOI: 10.1021/jacs.2c04835

Source: DNA nets capture COVID-19 virus in low-cost rapid-testing platform

Nanoengineers at the University of California San Diego have developed microscopic robots, called microrobots, that can swim around in the lungs, deliver medication and be used to clear up life-threatening cases of bacterial pneumonia.

In mice, the microrobots safely eliminated pneumonia-causing bacteria in the lungs and resulted in 100% survival. By contrast, untreated mice all died within three days after infection.

The results are published Sept. 22 in Nature Materials.

The microrobots are made of algae cells whose surfaces are speckled with antibiotic-filled nanoparticles. The algae provide movement, which allows the microrobots to swim around and deliver antibiotics directly to more bacteria in the lungs. The nanoparticles containing the antibiotics are made of tiny biodegradable polymer spheres that are coated with the cell membranes of neutrophils, which are a type of white blood cell. What’s special about these cell membranes is that they absorb and neutralize inflammatory molecules produced by bacteria and the body’s immune system. This gives the microrobots the ability to reduce harmful inflammation, which in turn makes them more effective at fighting lung infection.

[…]

The team used the microrobots to treat mice with an acute and potentially fatal form of pneumonia caused by the bacteria Pseudomonas aeruginosa. This form of pneumonia commonly affects patients who receive mechanical ventilation in the intensive care unit. The researchers administered the microrobots to the lungs of the mice through a tube inserted in the windpipe. The infections fully cleared up after one week. All mice treated with the microrobots survived past 30 days, while untreated mice died within three days.

Treatment with the microrobots was also more effective than an IV injection of antibiotics into the bloodstream. The latter required a dose of antibiotics that was 3000 times higher than that used in the microrobots to achieve the same effect. For comparison, a dose of microrobots provided 500 nanograms of antibiotics per mouse, while an IV injection provided 1.644 milligrams of antibiotics per mouse.

The team’s approach is so effective because it puts the medication right where it needs to go rather than diffusing it through the rest of the body.

[…]

the researchers say that this approach is safe. After treatment, the body’s immune cells efficiently digest the algae, along with any remaining nanoparticles. “Nothing toxic is left behind,” said Wang.

[…]

Source: Tiny swimming robots treat deadly pneumonia i | EurekAlert!

Journal: Nanoparticle-modified microrobots for in vivo antibiotic delivery to treat acute bacterial pneumonia | nature materials

Cure of acute deafness after bang, shots or explosion appears possibleNews item | 21-09-2022 | 12:12There are plenty of preventive measures to prevent hearing damage, such as acute deafness, for example during the use of weapons. And yet things go wrong with some regularity. However, there is a method to limit the damage after noise trauma. This is done with hyperbaric oxygen therapy. The use of this treatment method for so-called noise trauma occurs worldwide, especially among soldiers. The 150th has now been treated in the Netherlands, most of which have had good results.Enlarge Image 3 soldiers with weapon and the attack, in rural area, at night.Acute deafness can occur during shooting, but also from fireworks, for example.“As long as you act quickly”, emphasizes captain-at-sea doctor Robert Weenink. “And I mean within 72 hours.”This anesthesiologist applies the therapy in the Amsterdam University Medical Center. Of course, not only soldiers benefit from this, but everyone who suffers from acute deafness from loud noise. This can also be the result of, for example, fireworks.Enlarge Image Burnt firecrackers in the street.Firecrackers can be disastrous for the hearing.Less damageThe fact that there is now a therapy is quite special. Not so long ago, deafness after noise trauma was actually a matter of bad luck. According to Weenink, there were medicines that helped something, but nothing else could be done about it. Until reports from abroad came to the attention of doctors at the Ministry of Defense. “Hyperbaric oxygen therapy could lead to less damage to hearing,” says Weenink. “Treatment with this was introduced for military personnel at the time.”Enlarge Image A recompression chamber, known from the diving world.A recompression chamber, known from the diving world.ciliaThe therapy is painless. The patient breathes 100% oxygen for 1.5 hours. This takes place in a recompression chamber known from the diving world, at a pressure that corresponds to a dive of 14 meters. During the 10 treatments required, the body receives a very large amount of oxygen, which also arrives in the inner ear and repairs damaged cilia.Enlarge Image A recompression chamber.The inside of a recompression chamber.By bang, shots or explosionOnly military personnel and police officers with significant hearing loss after noise trauma caused by a bang, shots or explosion are eligible for hyperbaric oxygen therapy. Weenink: “That is because less hearing loss usually recovers well without this treatment.” Unfortunately, people who now have permanent damage after prolonged exposure to noise are also not eligible. It’s really about the acute phase.Dutch ‘invention’Applying hyperbaric oxygen therapy is a Dutch ‘invention’. The Amsterdam surgeon Professor Ite Boerema was the founder of this treatment and has put it on the international map. The therapy is used to treat a variety of diseases, not specific to acute noise trauma. In the Netherlands, Defense is a forerunner in this field.

Source (Dutch): Genezing van acute doofheid na knal, schoten of ontploffing blijkt mogelijk

Source (Translate): Cure of acute deafness after bang, shots or explosion appears possible | News item | Defense.nl

[…] The Galleri test has been described as a potential “gamechanger” by NHS England, which is due to report results from a major trial involving 165,000 people next year. Doctors hope the test will save lives by detecting cancer early enough for surgery and treatment to be more effective, but the technology is still in development.

“I think what’s exciting about this new paradigm and concept is that many of these were cancers for which we do not have any standard screening,” Dr Deb Schrag, a senior researcher on the study at the Memorial Sloan Kettering Cancer Center in New York, told the European Society for Medical Oncology meeting in Paris on Sunday.

In the Pathfinder study, 6,621 adults aged 50 and over were offered the Galleri blood test. For 6,529 volunteers, the test was negative, but it flagged a potential cancer in 92.

Further tests confirmed solid tumours or blood cancer in 35 people, or 1.4% of the study group. The test spotted two cancers in a woman who had breast and endometrial tumours.

Beyond spotting the presence of disease, the test predicts where the cancer is, allowing doctors to fast-track the follow-up work needed to locate and confirm a cancer. “The signal of origin was very helpful in directing the type of work-up,” said Schrag. “When the blood test was positive, it typically took under three months to get the work-ups completed.”

The test identified 19 solid tumours in tissues such as the breast, liver, lung and colon, but it also spotted ovarian and pancreatic cancers, which are typically detected at a late stage and have poor survival rates.

The remaining cases were blood cancers. Out of the 36 cancers detected in total, 14 were early stage and 26 were forms of the disease not routinely screened for.

Further analyses found the blood test was negative for 99.1% of those who were cancer-free, meaning only a small proportion of healthy people wrongly received a positive result. About 38% of those who had a positive test turned out to have cancer.

Schrag said the test was not yet ready for population-wide screening and that people must continue with standard cancer screening while the technology is improved. “But this still suggests a glimpse of what the future may hold with a really very different approach to cancer screening,” she said.

[…]

Source: Blood test spots multiple cancers without clear symptoms, study finds

Researchers say they have cracked how air pollution leads to cancer, in a discovery that completely transforms our understanding of how tumours arise.

The team at the Francis Crick Institute in London showed that rather than causing damage, air pollution was waking up old damaged cells.

One of the world’s leading experts, Prof Charles Swanton, said the breakthrough marked a “new era”.

And it may now be possible to develop drugs that stop cancers forming.

The findings could explain how hundreds of cancer-causing substances act on the body.

The classical view of cancer starts with a healthy cell. It acquires more and more mutations in its genetic code, or DNA, until it reaches a tipping point. Then it becomes a cancer and grows uncontrollably.

[…]

• around one in every 600,000 cells in the lungs of a 50-year-old already contains potentially cancerous mutations
• These are acquired as we age but appear completely healthy until they are activated by the chemical alarm and become cancerous

Crucially, the researchers were able to stop cancers forming in mice exposed to air pollution by using a drug that blocks the alarm signal.

The results are a double breakthrough, both for understanding the impact of air pollution and the fundamentals of how we get cancer.

[…]

Source: Air pollution cancer breakthrough will rewrite the rules – BBC News

[…]

What is pyramid salt?

Pyramid salt crystals are made of the same stuff as regular salt. But these crystals look different because they formed in a different way.

In nature, these elusive crystals grow on the surface of quiet, undisturbed pools of salt water that evaporate under the hot sun.

Pyramid salt is more expensive than regular salt, because they taste saltier. Pyramid salt is hollow, and gram for gram, it dissolves in your mouth faster than regular salt. So the saltiness comes at your taste buds all at once.

Plus, they also look awesome.

Now, it’s easy to make regular salt crystals at home. Just leave a dish of salt water to evaporate, and you’ll get white powdery salt inside after a few hours.

However, it’s much harder to make pyramid salt.

True, you can buy them online. Maldon Sea Salt, for instance, contains crunchy pyramidal salt crystals. They are made by evaporating sea water in large heated pans, mimicking nature.

But that kind of salt is produced industrially, with special equipment and mineral rich seawater.

I’ve always wondered whether you could grow pyramids at home using a hot plate, a glass dish and some regular table salt.

It took over 100 experiments and some sleepless nights, but here are the results.

How to make pyramid salt crystals

This guide will consist of the following parts:

1. Materials
2. Preparing the salt solution
3. Growing the pyramid salt crystals
4. Harvesting the pyramid salt crystals
5. Storing the pyramid salt crystals
6. Tasting the pyramid salt crystals
7. 8 types of pyramid salt crystals
8. Some more information
9. Summary

Materials

To make pyramid salt crystals, you’ll need:

• A bag of salt
• Alum powder
• A stove/hot plate
• A heat resistant glass dish
• A pair of tweezers
• A thermometer (optional)

I have tried table salt, sea salt, and Himalayan rock salt, and they all work. Sea salt seems to give better results.

I’ve used both tap and deionized water. Both are fine.

Also, in this experiment, we’ll be heating some very concentrated salt water. This solution will damage metallic objects, so you can’t use a stainless steel pot.

Instead, I suggest using a heat resistant glass dish. The exact type doesn’t matter. You can use a Pyrex dish or an enameled cast iron pot, which won’t get corroded.

I used a glass casserole.

Preparing the salt solution

Dissolve 165 g of salt in 500 mL of hot water. If you want to make a bigger batch, just use the same ratio (e.g. 330 g of salt per 1 L of water).

Stir the solution gently until all of it dissolves.

Depending on whether the salt is dirty, you can choose to filter it. I filtered mine.

In my setup, I poured my filtered salt solution into a glass casserole sitting on top of a hot plate.

A hot plate is fine. But don’t put the glass dish directly on the gas stove – the glass might break due to strong, uneven heating, even though it is technically heat resistant. Use a water bath instead.

Growing the pyramid salt crystals

Now, heat the solution to 60-70°C and keep it there throughout the growing process.

When the solution warms up, convection currents start forming, causing the surface of the solution to swirl around.

This is bad news, because when our pyramids form, they will also move around the surface of the solution. And they will bump into each other, stick together and fall to the bottom of the dish.

The key is to add an ingredient called potassium alum. Alum calms the surface and helps the pyramids form. It is normally used in baking and pickling. You can find it at the grocery store, or buy it online.

Add 0.5 g of alum per 500 mL of salt solution. No need to measure – just drop a few pea-sized pieces of alum/two pinches of alum powder into the solution and let it dissolve.

Several minutes after the alum has dissolved, the surface of the solution should start to settle down. Check out this GIF:

I placed a cork on the surface of the solution to visualize the movement on the surface. Before adding alum, the cork swirled around. After adding alum, the cork was completely motionless.

Good. Now you just need to wait.

It takes about 30 minutes for the salt solution to reach saturation, which is the point where salt crystals start to form.

Eventually, small white squares will appear on the surface of the solution.

Those are baby pyramid salt crystals.

They’ll keep growing, and within 15 minutes they’ll look like this:

The crystals are actually upside down pyramids, suspended on the surface of the solution due to surface tension. It’s the same principle that lets some insects walk on water.

Here’s what they look like from the side:

As the pyramid salt crystals get heavier, they sink lower into the solution. But evaporation on the surface causes the base of the pyramids to grow outwards, widening it and forming a staircase pattern in the process.

Super cool.

Here’s a time lapse of the growing process over 1 hour:

As the pyramids get larger, they risk bumping into their neighbors.

Usually, it isn’t a big problem – unless your solution is too hot. If you heat it beyond 80°C, the pyramids quickly join together to form a layer of crust.

But even at 60°C, you shouldn’t leave them there, because they might get too heavy and fall to the bottom to the dish.

So it’s time to harvest the pyramids.

Harvesting the pyramid salt crystals

Using a pair of tweezers, carefully remove the pyramid that you want, and place it on a piece of tissue paper. The paper will soak up excess salt solution.

Before you remove the second pyramid, dip the tweezers in a cup of water. This step ensures that there are no powdery salt grains sticking to your tweezers – which will cause thousands of tiny crystals to form in the dish.

Then, dry the tweezers with a tissue, and remove your second pyramid. Rinse and repeat.

Instead of using tweezers, you can also use a sieve to scoop up those pyramids. Remember to dip the sieve in water after every run.

Wash your tweezers after every run to prevent powdery salt grains from forming.

You can keep doing this until the salt water starts to dry out. By this time, you should have quite a few pyramids.

And that’s it!

You’ve just made the fabled pyramid salt, also known as fleur de sel, flower of salt, at home.

If you want to make more pyramids, just add some water to the dish and wait for all the salt to re-dissolve. Then repeat the process. This time, you don’t need to add alum.

Re-dissolving the salt to make more pyramids.

Storing the pyramid salt crystals

Just store them like regular salt.

If you live somewhere humid, the crystals will absorb moisture from the air and get slightly wet. This will cause part of the pyramid’s base to dissolve.

It’s no big deal, but if you want to prevent this, store the pyramid salt crystals with a desiccant.

[…]

Summary

That’s all for now. I have been trying to grow pyramid salt crystals for a very long time, and I’m glad to share what I’ve learnt with you. Hopefully you found the guide useful.

Here’s a super short summary of what we’ve covered.

To grow pyramid salt crystals, you’ll need:

• A bag of salt
• Alum powder
• A stove/hot plate
• A heat resistant glass dish
• A pair of tweezers
• A thermometer (optional)

1. Dissolve 165 g salt per 500 mL of water.
2. Heat the solution to 60°C.
3. Add 0.5 g alum per 500 mL of solution.
4. Wait for pyramids to form.
5. Remove the pyramids with tweezers.
6. Dry and store them with a desiccant.
7. Enjoy your pyramid salt. […]

Source: How to Easily Make Your Own Pyramid Salt Crystals – Crystalverse

[…]

Typically, when you want to characterize a wave of light, you have to use different instruments to gather information, such as the intensity, wavelength and polarization state of the light. Those instruments are bulky and can occupy a significant area on an optical table,” said Dr. Fan Zhang, a corresponding author of the study and associate professor of physics in the School of Natural Sciences and Mathematics.

“Now we have a single device—just a tiny and thin chip—that can determine all these properties simultaneously in a very short time,” he said.

The device exploits the unique physical properties of a novel family of two-dimensional materials called moiré metamaterials. Zhang, a theoretical physicist, published a review article on these materials Feb. 2 in Nature.

The 2D materials have periodic structures and are atomically thin. If two layers of such a material are overlaid with a small rotational twist, a moiré pattern with an emergent, orders-of-magnitude larger periodicity can form. The resulting moiré metamaterial yields electronic properties that differ significantly from those exhibited by a single layer alone or by two naturally aligned layers.

The sensing device that Zhang and his colleagues chose to demonstrate their new idea incorporates two layers of relatively twisted, naturally occurring bilayer graphene, for a total of four atomic layers.

“The moiré metamaterial exhibits what’s called a bulk photovoltaic effect, which is unusual,” said Patrick Cheung, a physics doctoral student at UT Dallas and co-lead author of the study. “Normally, you have to apply a voltage bias to produce any current in a material. But here, there is no bias at all; we simply shine a light on the moiré metamaterial, and the light generates a current via this bulk photovoltaic effect. Both the magnitude and phase of the photovoltage are strongly dependent on the light intensity, wavelength and polarization state.”

By tuning the moiré metamaterial, the photovoltage generated by a given incoming light wave creates a 2D map that is unique to that wave—like a fingerprint—and from which the wave’s properties might be inferred, although doing so is challenging, Zhang said.

Researchers in Dr. Fengnian Xia’s lab at Yale University, who constructed and tested the device, placed two metal plates, or gates, on top and underneath the moiré metamaterial. The two gates allowed the researchers to tune the quantum geometric properties of the material to encode the infrared light waves’ properties into “fingerprints.”

The team then used a convolutional neural network—an artificial intelligence algorithm that is widely used for image recognition—to decode the fingerprints.

“We start with light for which we know the intensity, wavelength and polarization, shine it through the device and tune it in different ways to generate different fingerprints,” Cheung said. “After training the neural network with a data set of about 10,000 examples, the network is able to recognize the patterns associated with these fingerprints. Once it learns enough, it can characterize an unknown light.”

[…]

Source: Physicists invent intelligent quantum sensor of light waves

[…]

If you couldn’t get a COVID vaccine, or if you got it but are in the group of people who likely aren’t as well protected, you can get Evusheld for an extra layer of protection.

What is Evusheld?

Evusheld is considered “pre-exposure prophylaxis” for COVID, and is available for people who are moderately to severely immunocompromised. The CDC has guidelines about Evusheld here. Evusheld is given every 6 months.

The treatment consists of two injections of monoclonal antibodies, tixagevimab and cilgavimab. In other words, instead of triggering your body to produce its own antibodies, you’re being given some ready-made antibodies. You should still also get your COVID vaccine, if you’re able to.

Who can get Evusheld?

Evusheld is for people who are moderately or severely immunocompromised or who are unable to be fully vaccinated with one of the regular COVID vaccines (for example, if you had an allergic reaction to your first dose or if you know you are allergic to a component of the vaccine). You also need to be at least 12 years old and weigh at least 88 pounds.

[…]

Source: What Is Evusheld? COVID Protection for Immunocompromised People

[…]

Since the 1970s, scientists believed that diamonds might actually rain down toward the mostly slushy planets’ rocky interiors—a diamond rain, if you will.

In 2017, researchers in Germany and California found a way to replicate those planetary conditions, fabricating teeny tiny diamonds called nanodiamonds in the lab using polystyrene (aka Styrofoam). Five years later and they’re back at it again, this time using some good ol’ polyethylene terephthalate (PET), according to a study published on Friday in Science Advances. The research has implications not only for our understanding of space, but paves a path toward creating nanodiamonds that are used in a range of contexts out of waste plastic.

[…]

When Kraus and his colleagues first attempted making nanodiamonds with polystyrene—which contains the same elements of carbon and hydrogen found on Neptune and Uranus—they did so by bombarding the material with the Linac Coherent Light Source, a high-powered X-ray laser at the SLAC National Acceleratory Laboratory in California. This process rapidly heated the polystyrene to 5,000 Kelvin (around 8,540 degrees Fahrenheit) and compressed it by 150 gigapascals, similar to conditions found about 6,000 miles into the interior of the icy planets.

While the researchers were able to make the microscopic bling with two quick hits from the laser, they later realized one vital chemical ingredient was missing: oxygen. So they turned to PET, which has a good balance of not only carbon and hydrogen but also oxygen, making it a closer chemical proxy to the ice giants than polystyrene.

[…]

“We found that the presence of oxygen enhances diamond formation instead of preventing it, making ‘diamond rain’ inside those planets a more likely scenario,” said Kraus. “We [also] see that diamonds grow larger for higher pressures and with progressing time in the experiments.”

They were also able to squeeze out a lot of tiny diamonds from just one shot of X-ray, on the order of a few billion crystallites (or a few micrograms if you’re talking total weight).

[…]

“If industrial scaling of the formation process indeed works as discussed above, and nanodiamonds will be required in very large quantitates for certain processes, e.g., catalysis for light-induced CO2 reduction reactions helping to reduce global warming, this may indeed become a potential way to recycle large amounts of PET,”  said Kraus.

[…]

Source: Scientists Turn Plastic Into Diamonds In Breakthrough

[…]

China’s National Medical Products Administration approved CanSino’s Ad5-nCoV for emergency use as a booster vaccine, the company said in a statement to the Hong Kong Stock Exchange on Sunday.

The vaccine is a new version of CanSino’s one-shot Covid drug, the first in the world to undergo human testing in March 2020 and which has been used in China, Mexico, Pakistan, Malaysia and Hungary after being rolled out in February 2021. The inhaled version can stimulate cellular immunity and induce mucosal immunity to boost protection without intramuscular injection, CanSino said.

[…]

CanSino’s initial one-shot vaccine was found to be 66% effective in preventing Covid-19 symptoms and 91% effective against severe disease, but it trails vaccines from Sinovac Biotech Ltd. and state-owned Sinopharm Group Co. in use outside China. Those two companies account for most of the 770 million doses China has sent to the rest of the world.

The vaccine, which uses a modified cold-causing virus to expose the immune system to the coronavirus, is similar to those developed by AstraZeneca Plc and Johnson & Johnson.

Source: China Approves World’s First Covid Vaccine You Inhale – Bloomberg

The most common analytical method within population genetics is deeply flawed, according to a new study from Lund University in Sweden. This may have led to incorrect results and misconceptions about ethnicity and genetic relationships. The method has been used in hundreds of thousands of studies, affecting results within medical genetics and even commercial ancestry tests. The study is published in Scientific Reports.

[…]

The field of paleogenomics, where we want to learn about ancient peoples and individuals such as Copper age Europeans, heavily relies on PCA. PCA is used to create a genetic map that positions the unknown sample alongside known reference samples. Thus far, the unknown samples have been assumed to be related to whichever reference population they overlap or lie closest to on the map.

However, Elhaik discovered that the unknown sample could be made to lie close to virtually any reference population just by changing the numbers and types of the reference samples, generating practically endless historical versions, all mathematically “correct,” but only one may be biologically correct.

In the study, Elhaik has examined the twelve most common population genetic applications of PCA. He has used both simulated and real genetic data to show just how flexible PCA results can be. According to Elhaik, this flexibility means that conclusions based on PCA cannot be trusted since any change to the reference or test samples will produce different results.

Between 32,000 and 216,000 scientific articles in genetics alone have employed PCA for exploring and visualizing similarities and differences between individuals and populations and based their conclusions on these results.

[…]

More information: Eran Elhaik, Principal Component Analyses (PCA)-based findings in population genetic studies are highly biased and must be reevaluated, Scientific Reports (2022). DOI: 10.1038/s41598-022-14395-4

Journal information: Scientific Reports

Source: Study reveals flaws in popular genetic method

AI software capable of mapping tumor tissue more accurately to help surgeons treat and shrink prostate cancer using a laser-powered needle will soon be tested in real patients during clinical trials.

The National Cancer Institute estimated that approximately 12.6 percent of men will be diagnosed with prostate cancer at some point in their life. The risk for developing the disease rises over time for men over the age of 50. It’s one of the most curable forms of cancer, considering most cases are caught in the early stages due to regular screening tests.

Treatment for prostate cancer varies depending on the severity of the disease. Patients can undergo hormone therapy, chemotherapy, or surgery to remove tissue. Avenda Health, a medical startup founded in 2017, is developing a new type of treatment that is less invasive. The US Food and Drug Administration (FDA) granted an investigational device exemption (IDE) to the company’s invention this week, meaning it can now be used in a clinical study.

Patients will need to have an MRI scan and a targeted fusion biopsy performed first. The data is processed by Avenda’s AI algorithms in its iQuest software to map where the cancerous cells are located within the prostate. Next, the computer vision-aided model will simulate where best to insert FocalPoint, a probe armed with a laser, to help surgeons treat the patient’s tumor. The heat from the laser gently heats the cancerous cells and kills them with goal of shrinking and removing the whole tumor.

MRI images where cancer is mapped using iQuest software before and after treatment. Image Credit: Avenda Health

“Historically, prostate cancer treatments of surgery or radiation impacts critical structures like the urethra and nerves which control sexual and urinary function,” Avenda’s CEO and co-founder Shyam Natarajan told The Register. “Our focal laser ablation system, FocalPoint, which is powered by our AI-driven cancer margin software, iQuest, specifically targets tumor tissue and avoids healthy tissue. This means patients no longer lose control over these functions that are so common with traditional treatments, so quality of life is significantly improved.”

The treatment is only effective for men diagnosed with intermediate risk of prostate cancer, a classification that describes tumors being confined within the prostate only. Patients are considered high risk in cases where the cancer has spread beyond the prostate.

“This is one of the benefits of the iQuest software. Not only can it map the cancer, but it also provides decision support for the physician as they determine the best course of treatment for an individual patient. Not every patient is going to be eligible for focal therapy, and it is important for the physician to distinguish between good focal therapy candidates and not.  iQuest provides useful insights for that decision making process,”  Natarajan said.

[…]

Source: AI laser probe for prostate cancer enters clinical trials • The Register

[…]

esearchers at the Rockefeller University, in New York, were baffled when mosquitoes were somehow still able to find people to bite after having an entire family of human odour-sensing proteins removed from their genome.

The team then examined odour receptors in the antennae of mosquitoes, which bind to chemicals floating around in the environment and signal to the brain via neurons.

“We assumed that mosquitoes would follow the central dogma of olfaction, which is that only one type of receptor is expressed in each neuron,” said Younger. “Instead, what we’ve seen is that different receptors can respond to different odours in the same neuron.”

This means losing one or more receptors does not affect the ability of mosquitoes to pick up on human smells. This backup system could have evolved as a survival mechanism, the researchers say.

“The mosquito Aedes aegypti is specialised to bite humans, and it is believed that they evolved to do that because humans are always close to fresh water and mosquitoes lay their eggs in fresh water. We are basically the perfect meal, so the drive to find humans is extremely strong,” said Younger.

Ultimately, the researchers say, understanding how the mosquito brain processes human odour could be used to intervene in biting behaviour and reduce the spread of mosquito-borne diseases, such as malaria, dengue and yellow fever.

[…]

Source: Scientists discover how mosquitoes can ‘sniff out’ humans | Animal behaviour | The Guardian

A new study corrects an important error in the 3D mathematical space developed by the Nobel Prize-winning physicist Erwin Schrödinger and others, and used by scientists and industry for more than 100 years to describe how your eye distinguishes one color from another. The research has the potential to boost scientific data visualizations, improve TVs and recalibrate the textile and paint industries.

[…]

“Our research shows that the current mathematical model of how the eye perceives color differences is incorrect. That model was suggested by Bernhard Riemann and developed by Hermann von Helmholtz and Erwin Schrödinger—all giants in mathematics and physics—and proving one of them wrong is pretty much the dream of a scientist,” said Bujack.

[…]

the team was surprised when they discovered they were the first to determine that the longstanding application of Riemannian geometry, which allows generalizing straight lines to curved surfaces, didn’t work.

To create industry standards, a precise mathematical model of perceived color space is needed. First attempts used Euclidean spaces—the familiar geometry taught in many high schools; more advanced models used Riemannian geometry. The models plot red, green and blue in the 3D space. Those are the colors registered most strongly by light-detecting cones on our retinas, and—not surprisingly—the colors that blend to create all the images on your RGB computer screen.

In the study, which blends psychology, biology and mathematics, Bujack and her colleagues discovered that using Riemannian geometry overestimates the perception of large color differences. That’s because people perceive a big difference in color to be less than the sum you would get if you added up small differences in color that lie between two widely separated shades.

Riemannian geometry cannot account for this effect.

“We didn’t expect this, and we don’t know the exact geometry of this new color space yet,” Bujack said. “We might be able to think of it normally but with an added dampening or weighing function that pulls long distances in, making them shorter. But we can’t prove it yet.”

Source: Math error: A new study overturns 100-year-old understanding of color perception

More information: Roxana Bujack et al, The non-Riemannian nature of perceptual color space, Proceedings of the National Academy of Sciences (2022). DOI: 10.1073/pnas.2119753119

[…] Here, we used the LIBRA-seq technology, which identified SARS-CoV-2 specific B cells via DNA-barcoding and subsequently single cell sequenced BCRs, to identify an antibody, SW186, which could neutralize major SARS-CoV-2 variants of concern, including Beta, Delta, and Omicron, as well as SARS-CoV-1. The cryo-EM structure of SW186 bound to the receptor-binding domain (RBD) of the viral spike protein showed that SW186 interacted with an epitope of the RBD that is not at the interface of its binding to the ACE2 receptor but highly conserved among SARS coronaviruses. This epitope encompasses a glycosylation site (N343) of the viral spike protein. Administration of SW186 in mice after they were infected with SARS-CoV-2 Alpha, Beta, or Delta variants reduced the viral loads in the lung. These results demonstrated that SW186 neutralizes diverse SARS coronaviruses by binding to a conserved RBD epitope, which could serve as a target for further antibody development.

[…]

Source: An antibody that neutralizes SARS-CoV-1 and SARS-CoV-2 by binding to a conserved spike epitope outside the receptor binding motif – Science Immunology

[…]

In a paper appearing today in Science, the engineers present the design for a new ultrasound sticker — a stamp-sized device that sticks to skin and can provide continuous ultrasound imaging of internal organs for 48 hours.

The researchers applied the stickers to volunteers and showed the devices produced live, high-resolution images of major blood vessels and deeper organs such as the heart, lungs, and stomach. The stickers maintained a strong adhesion and captured changes in underlying organs as volunteers performed various activities, including sitting, standing, jogging, and biking.

The current design requires connecting the stickers to instruments that translate the reflected sound waves into images. The researchers point out that even in their current form, the stickers could have immediate applications: For instance, the devices could be applied to patients in the hospital, similar to heart-monitoring EKG stickers, and could continuously image internal organs without requiring a technician to hold a probe in place for long periods of time.

If the devices can be made to operate wirelessly — a goal the team is currently working toward — the ultrasound stickers could be made into wearable imaging products that patients could take home from a doctor’s office or even buy at a pharmacy.

“We envision a few patches adhered to different locations on the body, and the patches would communicate with your cellphone, where AI algorithms would analyze the images on demand,” says the study’s senior author, Xuanhe Zhao, professor of mechanical engineering and civil and environmental engineering at MIT. “We believe we’ve opened a new era of wearable imaging: With a few patches on your body, you could see your internal organs.”

[…]

The MIT team’s new ultrasound sticker produces higher resolution images over a longer duration by pairing a stretchy adhesive layer with a rigid array of transducers. “This combination enables the device to conform to the skin while maintaining the relative location of transducers to generate clearer and more precise images.” Wang says.

The device’s adhesive layer is made from two thin layers of elastomer that encapsulate a middle layer of solid hydrogel, a mostly water-based material that easily transmits sound waves. Unlike traditional ultrasound gels, the MIT team’s hydrogel is elastic and stretchy.

“The elastomer prevents dehydration of hydrogel,” says Chen, an MIT postdoc. “Only when hydrogel is highly hydrated can acoustic waves penetrate effectively and give high-resolution imaging of internal organs.”

The bottom elastomer layer is designed to stick to skin, while the top layer adheres to a rigid array of transducers that the team also designed and fabricated. The entire ultrasound sticker measures about 2 square centimeters across, and 3 millimeters thick — about the area of a postage stamp.

The researchers ran the ultrasound sticker through a battery of tests with healthy volunteers, who wore the stickers on various parts of their bodies, including the neck, chest, abdomen, and arms. The stickers stayed attached to their skin, and produced clear images of underlying structures for up to 48 hours. During this time, volunteers performed a variety of activities in the lab, from sitting and standing, to jogging, biking, and lifting weights.

[…]

Source: MIT engineers develop stickers that can see inside the body | MIT News | Massachusetts Institute of Technology

Researchers are studying the electrical rhythms in plant cells.

Source: Rhythm in plant cells | FlowingData