A small clinical trial conducted at the Murdoch Children’s Research Institute has led to two-thirds of children treated with an experimental immunotherapy treatment being cured of their allergy. Importantly, this desensitisation to peanuts persisted for up to four years after treatment.
Forty-eight children were enrolled in the PPOIT trial and were randomly given either a combination of the probiotic Lactobacillus rhamnosus with peanut protein in increasing amounts, or a placebo, once daily for 18 months.
At the end of the original trial in 2013, 82% of children who received the immunotherapy treatment were deemed tolerant to peanuts compared with just 4% in the placebo group.
Four years later, the majority of the children who gained initial tolerance were still eating peanuts as part of their normal diet and 70% passed a further challenge test to confirm long-term tolerance.